{"id":"W4394715993","doi":"10.1016/j.cell.2024.03.018","title":"Self-amplifying RNA COVID-19 vaccine","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Biology; Christian ministry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Virology; Download; RNA; Clinical trial; Bioinformatics; Genetics; Internal medicine; Outbreak; Medicine; Gene; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008032814,0.00009458022,0.00006574714,0.00003335069,0.00004400117,0.00004422323,0.0001335879,0.00008581615,0.0001372739],"category_scores_gemma":[0.00001617154,0.00008518097,0.00006917792,0.00006045428,0.000007764423,0.000002270619,0.00007117242,0.00006529384,0.0002999094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001703946,"about_ca_system_score_gemma":0.0001099941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001379042,"about_ca_topic_score_gemma":0.000008275688,"domain_scores_codex":[0.9994099,0.00001600381,0.0001004789,0.0002663108,0.00005291432,0.0001544267],"domain_scores_gemma":[0.9996457,0.00000965476,0.00001457604,0.0002054452,0.00002028071,0.000104392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001806007,0.00002615683,0.0001843507,0.0001561068,0.00003421627,0.00003151279,0.00010676,0.00003012696,0.9258892,0.0000370252,0.07243046,0.001056029],"study_design_scores_gemma":[0.0001348611,0.00009916756,0.00003240621,0.000007223968,0.0000142761,0.00001290861,0.00004519996,0.0001853552,0.4343966,0.00008449826,0.564876,0.0001115121],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959722,0.01141499,0.006512624,0.000613315,0.0006646949,0.0001277798,0.00001639362,0.0001070181,0.0208212],"genre_scores_gemma":[0.9921979,0.0007944294,0.0003852075,0.001249329,0.0003522834,0.000008843491,0.00006044058,0.00001645744,0.004935144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4924456,"threshold_uncertainty_score":0.3854829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583431319477469,"score_gpt":0.2753718037531283,"score_spread":0.2595374905583536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}