{"id":"W4394715993","doi":"10.1016/j.cell.2024.03.018","title":"Self-amplifying RNA COVID-19 vaccine","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Coronavirus disease 2019 (COVID-19); Biology; Christian ministry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Virology; Download; RNA; Clinical trial; Bioinformatics; Genetics; Internal medicine; Outbreak; Medicine; Gene; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139228,0.0004425111,0.0003496537,0.0003137469,0.0002174874,0.000450322,0.0003559512,0.0005028155,0.00327339],"category_scores_gemma":[0.0001852482,0.0001654291,0.0003178744,0.0001627398,0.0002326853,0.0002356448,0.0002893744,0.0009441017,0.001093878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000412224,"about_ca_system_score_gemma":0.000308488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003312098,"about_ca_topic_score_gemma":0.0004526005,"domain_scores_codex":[0.9996758,0.00004079228,0.00001721009,0.00007824582,0.00009937072,0.00008873526],"domain_scores_gemma":[0.9999101,0.00002182273,0.00002231701,0.00001331989,0.00001531024,0.00001717329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005924,0.00006338648,0.0000757018,0.00004111011,0.000006247245,0.00004594481,0.00001194352,0.0001573679,0.9945731,0.0007937132,0.0002539004,0.003877002],"study_design_scores_gemma":[0.00003481118,0.0004253273,0.0003021946,0.000005173228,0.00001987528,0.0001882716,0.00001147639,0.000942509,0.9893857,0.0001289445,0.008551165,0.000004559275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8959503,0.005059901,0.07147857,0.000808105,0.001261021,0.000545553,0.00219742,0.001004499,0.02169453],"genre_scores_gemma":[0.9471051,0.001631281,0.02572032,0.0002800658,0.0001020064,0.0002226326,0.00196058,0.000119881,0.0228582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00327339,"threshold_uncertainty_score":0.01095062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01583431319477469,"score_gpt":0.2753718037531283,"score_spread":0.2595374905583536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}