{"id":"W4394721118","doi":"10.1016/j.healun.2024.02.099","title":"An Exploration of Gene Expression Patterns Underlying Restrictive and Obstructive Chronic Lung Allograft Dysfunction (CLAD) Phenotypes Using Non-Negative Matrix Factorization","year":2024,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Phenotype; Gene; Gene expression; Medicine; Matrix (chemical analysis); Computational biology; Genetics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004429859,0.0003092221,0.0003002177,0.000784445,0.0002514832,0.0003854871,0.0001921736,0.0001909022,0.00100713],"category_scores_gemma":[0.0009770646,0.00009770673,0.0006621066,0.0006707541,0.0002042452,0.0002186901,0.0002505859,0.000371223,0.0002004333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585261,"about_ca_system_score_gemma":0.0003240365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002106552,"about_ca_topic_score_gemma":0.003320778,"domain_scores_codex":[0.9998324,0.00003959233,0.000009899642,0.00005830946,0.00002735752,0.00003242035],"domain_scores_gemma":[0.9996081,0.0001957173,0.00008154143,0.00002689587,0.00005241665,0.000035346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002786466,0.0004513127,0.4040793,0.0004082707,0.000583099,0.001056222,0.0006952701,0.01288592,0.3602451,0.003251944,0.003826807,0.2097302],"study_design_scores_gemma":[0.00009409873,0.0008141365,0.7723989,0.00006608838,0.0003834086,0.001908784,0.001019644,0.1961596,0.01278439,0.009248728,0.005042774,0.00007948937],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528979,0.001110485,0.04240526,0.0003988841,0.00003773338,0.00004783188,0.002172581,0.0001489209,0.0007804872],"genre_scores_gemma":[0.9785572,0.0003111565,0.01859235,0.00007245091,0.00003056856,0.00003611168,0.001786265,0.00001849727,0.0005954221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106552,"threshold_uncertainty_score":0.004188597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04571075631665803,"score_gpt":0.3481311832410168,"score_spread":0.3024204269243588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}