{"id":"W4394724444","doi":"10.1101/2024.04.10.588480","title":"Phenotypic and Transcriptomic Characterization of ElyC-Defective <i>Escherichia coli</i> Cells Reveal the Importance of ElyC in Cell Envelope Biology at Optimal and Sub-Optimal Temperatures","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Université de Montréal; Natural Sciences and Engineering Research Council of Canada; Knut och Alice Wallenbergs Stiftelse; Vetenskapsrådet; Kempe Foundation","keywords":"Escherichia coli; Phenotype; Biology; Envelope (radar); Transcriptome; Cell envelope; Characterization (materials science); Cell; Computational biology; Genetics; Cell biology; Gene; Nanotechnology; Gene expression; Computer science; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161196,0.0004561428,0.0006155018,0.0002918082,0.0003033052,0.0007256243,0.0002127995,0.0004501199,0.0008805178],"category_scores_gemma":[0.0002507188,0.0002032352,0.0004460665,0.0005215505,0.0003159784,0.000309991,0.0003623052,0.0008576151,0.0006917077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000307168,"about_ca_system_score_gemma":0.0002561182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466439,"about_ca_topic_score_gemma":0.001623102,"domain_scores_codex":[0.999673,0.00001620315,0.00001976086,0.0001212058,0.000100332,0.00006941987],"domain_scores_gemma":[0.9998075,0.0000360894,0.00006396387,0.00002077169,0.00004224659,0.00002943992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007599392,0.00001427497,0.001059592,0.00007027948,0.000005943212,0.00007233647,0.00002564417,0.0000968437,0.9971074,0.00004133579,0.000180873,0.001249484],"study_design_scores_gemma":[0.00001421499,0.0001793171,0.1214302,0.00007044433,0.00006159118,0.0006277402,0.0004195222,0.003623505,0.8635105,0.0002631629,0.009737342,0.00006246113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638088,0.001859457,0.006125677,0.0003875494,0.00008141898,0.00005069831,0.02504803,0.0005319462,0.002106393],"genre_scores_gemma":[0.9538286,0.001487956,0.01015749,0.0006939087,0.00004051564,0.0001806034,0.02785085,0.000426501,0.005333567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466439,"threshold_uncertainty_score":0.002945602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004762325952380369,"score_gpt":0.1889325327833811,"score_spread":0.1841702068310007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}