{"id":"W4394724484","doi":"10.1016/j.healun.2024.02.022","title":"CRISPR-Cas Genome Editing in Ex Vivo Human Lungs","year":2024,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"CRISPR; Ex vivo; Genome editing; Biology; Genome; Genetics; Human genome; Computational biology; Gene; In vivo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009005616,0.0002321282,0.0003939827,0.0002425296,0.0003299727,0.0007690313,0.0004522035,0.0007579821,0.005041985],"category_scores_gemma":[0.0003039003,0.0003233748,0.0004367832,0.0001330965,0.0004697893,0.0003049381,0.000354087,0.001237786,0.001041315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002252086,"about_ca_system_score_gemma":0.000349223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007646155,"about_ca_topic_score_gemma":0.001143213,"domain_scores_codex":[0.9994937,0.0001019027,0.00004579236,0.0001473947,0.0001357009,0.00007547394],"domain_scores_gemma":[0.9997656,0.00008164027,0.00003149323,0.00006827,0.00001819618,0.00003484022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002327206,0.00005232646,0.000210351,0.00007107202,0.00001701449,0.0002812704,0.00004465521,0.0004774429,0.9927775,0.001256689,0.0003879059,0.00419117],"study_design_scores_gemma":[0.00004090924,0.0001288595,0.00109426,0.00001131134,0.00002456126,0.001001743,0.00003281048,0.002180502,0.9858004,0.0002147237,0.009460731,0.000009316681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.825,0.004371491,0.1449638,0.0007435529,0.0005585397,0.0004519053,0.003986959,0.001931676,0.01799202],"genre_scores_gemma":[0.9702056,0.0007829217,0.01578481,0.0001772388,0.000020077,0.0001479124,0.001089354,0.0001852847,0.01160671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005041985,"threshold_uncertainty_score":0.0168671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005910863519720297,"score_gpt":0.3040681316903437,"score_spread":0.2981572681706234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}