{"id":"W4394725634","doi":"10.7554/elife.85964","title":"Statin-mediated reduction in mitochondrial cholesterol primes an anti-inflammatory response in macrophages by upregulating Jmjd3","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health; Ottawa Hospital Research Institute; Heart and Stroke Foundation of Canada","keywords":"Inflammatory response; Statin; Reduction (mathematics); Inflammation; Cholesterol; Medicine; Chemistry; Cancer research; Biology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922116,0.0002227905,0.0003281507,0.0001807446,0.0002736478,0.0002849686,0.000169818,0.0003062804,0.001449608],"category_scores_gemma":[0.0001267549,0.0001094485,0.0003495777,0.0001441449,0.0002429434,0.0001818705,0.0002705508,0.0005400484,0.0004100671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000275584,"about_ca_system_score_gemma":0.0003259879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009821829,"about_ca_topic_score_gemma":0.001741858,"domain_scores_codex":[0.9998086,0.00001923462,0.00001983407,0.00003479132,0.00004730189,0.00007026109],"domain_scores_gemma":[0.9999113,0.000009394151,0.00002684283,0.00001217032,0.00001462472,0.00002568687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002875218,0.00001471388,0.0003865625,0.00007976689,0.000008837388,0.00006684136,0.00001394748,0.0000199146,0.9978236,0.0000719708,0.00008172808,0.001144634],"study_design_scores_gemma":[0.00004608819,0.0001933705,0.01092623,0.00001256035,0.00002651551,0.000283146,0.00005374199,0.0002516422,0.9832655,0.00009936743,0.004836638,0.000005255845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795368,0.008493355,0.005645812,0.000763287,0.0002020364,0.00006481668,0.001896479,0.0002008541,0.003196625],"genre_scores_gemma":[0.9896827,0.002436263,0.00271942,0.000206338,0.00003677283,0.00004403894,0.0008326097,0.00002174148,0.00402011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001449608,"threshold_uncertainty_score":0.004849434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008947176140412454,"score_gpt":0.281438022722285,"score_spread":0.2724908465818725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}