{"id":"W4394726345","doi":"10.21203/rs.3.rs-4187055/v1","title":"Blinded, Randomized Tolerance Study of a Biologically Enhanced Nanogel with Endothelin-1 and Bradykinin Receptor Antagonist Peptides via Intra-Articular Injection for Osteoarthritis Treatment in Horses","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"European Commission; European Social Fund; European Regional Development Fund; Région Normandie; Arthritis Society","keywords":"Bradykinin; Antagonist; Endothelin receptor; Receptor antagonist; Endothelin receptor antagonist; Osteoarthritis; Receptor; Pharmacology; Medicine; Internal medicine; Chemistry; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003065599,0.001746979,0.004120519,0.000622863,0.0008217777,0.001270984,0.001352959,0.002753841,0.005356872],"category_scores_gemma":[0.002691511,0.0009388344,0.001183138,0.0003741422,0.002475413,0.001251875,0.0005757394,0.00317471,0.001270339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007785607,"about_ca_system_score_gemma":0.001618095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979819,"about_ca_topic_score_gemma":0.0008479499,"domain_scores_codex":[0.998292,0.0004858231,0.0001713888,0.0005270137,0.0001870732,0.0003366441],"domain_scores_gemma":[0.9977658,0.0004555559,0.0004861374,0.0004259105,0.0002928457,0.0005738328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9120749,0.06083346,0.00014801,0.0002435578,0.0002109825,0.00002672602,0.00007287189,0.0003435737,0.01896186,0.0001909434,0.0003033721,0.006589739],"study_design_scores_gemma":[0.3702807,0.6183322,0.001086217,0.00003642687,0.0003204185,0.00002761054,0.00006646729,0.0009491591,0.007411276,0.0003305523,0.001113031,0.00004598977],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871836,0.0004636211,0.00224515,0.0001896313,0.0009374271,0.007586519,0.0004491343,0.00009628707,0.0008485712],"genre_scores_gemma":[0.9636248,0.0007335685,0.006343964,0.0007650737,0.0008069784,0.01859032,0.00066522,0.00007869999,0.00839138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005356872,"threshold_uncertainty_score":0.01792055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0384177917701474,"score_gpt":0.3543842276625097,"score_spread":0.3159664358923623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}