{"id":"W4394733947","doi":"10.1016/j.virusres.2024.199368","title":"Viral deubiquitinating proteases and the promising strategies of their inhibition","year":2024,"lang":"en","type":"article","venue":"Virus Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"European Commission; Horizon 2020; HORIZON EUROPE Framework Programme; University of Manitoba","keywords":"Deubiquitinating enzyme; Proteases; Ubiquitin; Biology; Innate immune system; Cell biology; Viral replication; Immune system; Enzyme; Biochemistry; Virus; Virology; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001668001,0.00007639773,0.0001311205,0.0001720923,0.0002485551,0.0001162515,0.00009762705,0.00008005149,0.0001454511],"category_scores_gemma":[0.0002620025,0.00004255875,0.00004585638,0.0001562204,0.001043582,0.0001378544,0.0001410005,0.000450319,0.00006383066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001930449,"about_ca_system_score_gemma":0.0001502337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003595646,"about_ca_topic_score_gemma":0.00002621141,"domain_scores_codex":[0.9984367,0.0009300484,0.0001775965,0.0001540099,0.00005465903,0.0002469531],"domain_scores_gemma":[0.9989093,0.0008335602,0.00002237456,0.0001250587,0.0001024842,0.000007232046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006953655,0.00002348669,0.00000517986,0.0001159838,0.00005188829,0.000003761349,0.002250612,3.023675e-7,0.9334094,0.0411863,0.000367557,0.02189016],"study_design_scores_gemma":[0.0005526078,0.0002552728,0.0001647199,0.0003091097,0.000005247234,0.00004731108,0.00551321,0.00005050083,0.9830825,0.003869168,0.006099878,0.00005043535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778129,0.01641964,0.00004655099,0.0004729082,0.00008373945,0.0004207592,0.00001550839,0.00003919903,0.004688776],"genre_scores_gemma":[0.9983701,0.000238799,0.00001077021,0.00001057451,0.00002170764,0.0000603758,0.000006673591,0.000009876388,0.001271157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04967314,"threshold_uncertainty_score":0.3845122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0488975071450755,"score_gpt":0.3582607874440098,"score_spread":0.3093632802989343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}