{"id":"W4394734977","doi":"10.1093/mutage/geae012","title":"A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma","year":2024,"lang":"en","type":"review","venue":"Mutagenesis","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pancreas Centre (Canada)","funders":"FP7 Health; Instituto de Salud Carlos III; Medical Research Council; Stand Up To Cancer; Associazione Italiana per la Ricerca sul Cancro; Humanitas Research Hospital; Università di Pisa; Cancer Research UK; Fondazione Arpa; Ministero della Salute; Szegedi Tudományegyetem; University of Oxford; Deutsches Krebsforschungszentrum","keywords":"Single-nucleotide polymorphism; Biology; Genome-wide association study; Pleiotropy; Genetics; Pancreatic cancer; Genetic association; Phenotype; Cancer; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005826323,0.001181933,0.001919065,0.003140866,0.0008975463,0.00113714,0.0008327148,0.0009946233,0.005808285],"category_scores_gemma":[0.008813317,0.0006384313,0.008301289,0.003621742,0.00047566,0.0006173074,0.001046871,0.001287099,0.000449205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003303964,"about_ca_system_score_gemma":0.0009320395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002474083,"about_ca_topic_score_gemma":0.004681278,"domain_scores_codex":[0.9959785,0.001934253,0.0003938917,0.001175511,0.0003480788,0.0001696261],"domain_scores_gemma":[0.9938996,0.003972156,0.0006706003,0.0007868996,0.0002775039,0.0003932124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00809011,0.000141813,0.7150867,0.003425055,0.1980193,0.003029922,0.0002512246,0.001643092,0.01770527,0.0008340169,0.002692612,0.04908081],"study_design_scores_gemma":[0.00134616,0.001705453,0.7778812,0.0007325864,0.1936915,0.005882289,0.0002794617,0.003286818,0.002730261,0.003034053,0.009345341,0.00008492159],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.820703,0.1459098,0.01958385,0.001875215,0.0006081344,0.0002535684,0.007165865,0.0004363234,0.003464225],"genre_scores_gemma":[0.9847872,0.007619408,0.004033039,0.0004535675,0.0002133747,0.000102331,0.002145966,0.00006640096,0.0005787622],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005826323,"threshold_uncertainty_score":0.03081292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1144330541588801,"score_gpt":0.4335271206321963,"score_spread":0.3190940664733162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}