{"id":"W4394739788","doi":"10.1101/pdb.over107759","title":"Structural Survey of Antigen Recognition by Synthetic Human Antibodies","year":2024,"lang":"en","type":"review","venue":"Cold Spring Harbor Protocols","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Computer science; Computational biology; Set (abstract data type); Antigen; Antibody; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008252793,0.000585563,0.002325202,0.0003561547,0.0001387439,0.00009474024,0.0003794258,0.000359718,0.0002409375],"category_scores_gemma":[0.0002333572,0.0004222211,0.0005993908,0.0004915654,0.0002572457,0.00006368779,0.0002678311,0.0008773405,0.0002732099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118449,"about_ca_system_score_gemma":0.0004269001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007037664,"about_ca_topic_score_gemma":0.00001920837,"domain_scores_codex":[0.9967257,0.0003324424,0.001057048,0.000696875,0.0006593509,0.0005285934],"domain_scores_gemma":[0.9983021,0.0002199919,0.0003710024,0.0005863958,0.0003022295,0.0002182594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004113219,0.0004871102,0.004450167,0.5960322,0.002934187,0.0004267889,0.00005443766,8.699201e-8,0.005108095,0.001410146,0.009597979,0.3790874],"study_design_scores_gemma":[0.0003266404,0.0004260701,0.0029013,0.0818886,0.0005903087,0.00001603528,0.000001121888,0.000008838221,0.001247009,0.00001687905,0.9120434,0.0005337788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00149883,0.9216321,0.000001689032,0.00001930513,0.00009692126,0.07523067,0.001053769,0.0001007909,0.0003659911],"genre_scores_gemma":[0.0004199169,0.9568962,0.0001458219,0.00001483005,0.0002449813,0.04042606,0.000221727,0.0001629149,0.001467562],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9024454,"threshold_uncertainty_score":0.999823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1803438034486515,"score_gpt":0.4415657072968743,"score_spread":0.2612219038482227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}