{"id":"W4394741358","doi":"","title":"Targeted development and optimization of small-molecule ice recrystallization inhibitors (IRIs) for the cryopreservation of biological systems.","year":2024,"lang":"en","type":"article","venue":"PubMed","topic":"Freezing and Crystallization Processes","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Cryopreservation; Recrystallization (geology); Antifreeze protein; Small molecule; Chemistry; Cell biology; Biochemistry; Biology; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611953,0.00007591584,0.00009799941,0.00007207388,0.00003586558,0.00003746646,0.00006393983,0.00006392701,0.000001958587],"category_scores_gemma":[0.0001542783,0.00005615278,0.00001806225,0.0002813064,0.00002619139,0.00008693993,0.00001461211,0.00003145215,8.643256e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002385,"about_ca_system_score_gemma":0.00001705269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004997894,"about_ca_topic_score_gemma":0.00000241047,"domain_scores_codex":[0.9994103,0.00001548648,0.0002807342,0.000104734,0.00008530926,0.0001034134],"domain_scores_gemma":[0.9996207,0.0001251951,0.00004700042,0.00006669313,0.0001179056,0.00002250392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00001250838,0.00001273813,0.0002111748,0.001414128,0.00007713,1.698163e-7,0.0003724645,0.9857415,0.001966092,0.001084872,0.0004233774,0.008683826],"study_design_scores_gemma":[0.0002080997,0.00001891586,0.001916262,0.0001230475,0.00003750984,0.000001404054,0.0002211646,0.9488579,0.03868689,0.00006294885,0.009717681,0.000148188],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.06898758,0.00727418,0.9223189,0.00005047522,0.0002819435,0.00076264,0.0000128505,0.0001700631,0.0001414042],"genre_scores_gemma":[0.9957776,0.0003081601,0.002999166,0.000004961747,0.00003438851,0.0007299415,0.00006939779,0.00001741182,0.00005894954],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9267901,"threshold_uncertainty_score":0.2289844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03238258284664286,"score_gpt":0.2024029133334424,"score_spread":0.1700203304867995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}