{"id":"W4394741783","doi":"10.1139/cjc-2023-0146","title":"Benzotriazepine synthesis, conformational analysis, and biological properties","year":2024,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Institute of Health Services and Policy Research; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Universities Space Research Association; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Ring (chemistry); Amide; Biological activity; Peptide; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186642,0.0003003674,0.0002830949,0.0002789576,0.0001321177,0.000185268,0.0002401482,0.0001737741,0.002589703],"category_scores_gemma":[0.0001659693,0.0001398684,0.0001912044,0.0003915738,0.0001395084,0.0003071773,0.0001357734,0.0004338258,0.001331683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003374752,"about_ca_system_score_gemma":0.0002495343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008769112,"about_ca_topic_score_gemma":0.001578333,"domain_scores_codex":[0.9999322,0.000008416188,0.000006658985,0.00001848884,0.00002150457,0.00001275822],"domain_scores_gemma":[0.9999603,0.00000582912,0.00001136028,0.00000426457,0.00001356252,0.000004734967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001812113,0.00005963849,0.0001769119,0.002136695,0.00004058754,0.0004140877,0.00008319768,0.001844101,0.9067495,0.00234508,0.0009734163,0.0849956],"study_design_scores_gemma":[0.00006277506,0.001640824,0.00285248,0.0001639987,0.0001127528,0.002073079,0.00005068174,0.0007375349,0.835412,0.0006558158,0.1561877,0.00005047515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3801072,0.5275047,0.02949246,0.0006919157,0.0003834676,0.0005720318,0.00275409,0.0004094315,0.05808472],"genre_scores_gemma":[0.5741453,0.3859372,0.01580723,0.0003553966,0.0001758131,0.0002260842,0.001836892,0.00008206222,0.0214339],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002589703,"threshold_uncertainty_score":0.008663416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02706396546430596,"score_gpt":0.2407601637666056,"score_spread":0.2136961983022996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}