{"id":"W4394748831","doi":"10.1016/j.molcel.2024.03.023","title":"Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling","year":2024,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Biology; Receptor; Cell biology; Signal transduction; Cytokine; Cytokine receptor; Cell surface receptor; Interleukin-6 receptor; Common gamma chain; Inflammation; Cell signaling; Immune system; Interleukin 10; Interleukin; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705772,0.0001594333,0.0002533105,0.0000581764,0.0001396126,0.0000189376,0.0005250789,0.0001299232,0.0008212485],"category_scores_gemma":[0.0000277992,0.00009061741,0.0001599091,0.0002873744,0.0003226741,0.00003071432,0.0001949566,0.0003370675,0.0000220932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002120494,"about_ca_system_score_gemma":0.00006584493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006901854,"about_ca_topic_score_gemma":0.000005833819,"domain_scores_codex":[0.9988576,0.0003825775,0.0003447717,0.0001668828,0.00005524954,0.0001928836],"domain_scores_gemma":[0.9991286,0.0001826676,0.0001330955,0.0004843615,0.00006578582,0.000005431955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060014,0.0000349318,0.0001294682,0.0000896864,0.0001975382,0.000001667412,0.001295592,0.0000384765,0.9958814,0.001158406,0.0003812755,0.000685504],"study_design_scores_gemma":[0.0002527041,0.00008488933,0.000424664,0.0001127333,0.00004974903,0.00001575874,0.0002477037,0.00000583144,0.9091972,0.00008142756,0.08943732,0.00009002582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983127,0.01520597,0.0002439151,0.0002878589,0.0005281857,0.0002215427,0.00007169107,0.00002943489,0.0002844213],"genre_scores_gemma":[0.9988617,0.00004913882,0.00006527159,0.0001366236,0.00001116126,0.000002447856,0.00004200413,0.00002855229,0.0008031358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08905605,"threshold_uncertainty_score":0.8992096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045512913602446,"score_gpt":0.2358437077220349,"score_spread":0.2253885785860104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}