{"id":"W4394748978","doi":"10.1016/j.cell.2024.03.019","title":"ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission; School of Medicine, Shanghai Jiao Tong University; Fudan University; National Natural Science Foundation of China","keywords":"Biology; Immunotherapy; Tumor microenvironment; Immune system; Cancer research; T cell; CD3; Antibody; T-cell receptor; Cell biology; Cancer immunotherapy; Immunology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002208087,0.0002521018,0.0002820962,0.0002323509,0.0002237849,0.00005914533,0.000213362,0.0002697718,0.001011748],"category_scores_gemma":[0.00002194663,0.0002158372,0.00008931417,0.0002560191,0.0001123457,0.0001411597,0.0002174238,0.0004286413,0.003909915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005932204,"about_ca_system_score_gemma":0.00008067094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001644713,"about_ca_topic_score_gemma":0.000004537197,"domain_scores_codex":[0.9985472,0.0001099428,0.0003039287,0.0005084702,0.00003642281,0.0004940259],"domain_scores_gemma":[0.9993577,0.0001503446,0.00006172385,0.0003449733,0.00004389802,0.00004137612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009645156,0.0001151247,0.00005053943,0.0001033747,0.0000341541,0.00001605007,0.0005601798,0.000003724173,0.9866505,0.0001116478,0.009891463,0.002366809],"study_design_scores_gemma":[0.0005860024,0.0002552007,0.0001302235,0.00004651321,0.00003128542,0.00003874855,0.0002672003,0.00001013222,0.7532735,0.0001317122,0.2450269,0.0002025545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697424,0.01267606,0.0002001634,0.0004963916,0.001616541,0.0003245304,0.0000143657,0.0002090178,0.01472058],"genre_scores_gemma":[0.9438489,0.0002560839,0.00009334386,0.000245083,0.000066754,0.00003104193,0.00009318857,0.00003649855,0.0553291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2351355,"threshold_uncertainty_score":0.9999015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008431370601874712,"score_gpt":0.2131070708959454,"score_spread":0.2046757002940706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}