{"id":"W4394748978","doi":"10.1016/j.cell.2024.03.019","title":"ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission; School of Medicine, Shanghai Jiao Tong University; Fudan University; National Natural Science Foundation of China","keywords":"Biology; Immunotherapy; Tumor microenvironment; Immune system; Cancer research; T cell; CD3; Antibody; T-cell receptor; Cell biology; Cancer immunotherapy; Immunology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092794,0.0006243277,0.0002332112,0.0002369165,0.0004007083,0.0006986055,0.0005308006,0.0007904148,0.007332542],"category_scores_gemma":[0.0002372022,0.0002517941,0.0004545917,0.0001458003,0.0003180617,0.0005635418,0.0005983214,0.001935604,0.002987782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000787081,"about_ca_system_score_gemma":0.000333751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004007031,"about_ca_topic_score_gemma":0.0004455687,"domain_scores_codex":[0.9996916,0.0000414645,0.0000127899,0.0000697285,0.00006551673,0.0001189428],"domain_scores_gemma":[0.9998952,0.0000119015,0.00002540374,0.00001361689,0.00001372103,0.0000401049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000325519,0.00005558118,0.0006457434,0.00008015522,0.00001716763,0.0002937954,0.00002859328,0.0003667179,0.9908816,0.001102278,0.001247069,0.004955846],"study_design_scores_gemma":[0.00005484905,0.0001963534,0.002041918,0.00001417109,0.00001254172,0.0008120014,0.00004910849,0.002822803,0.9802429,0.0003722275,0.01337165,0.000009571952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625286,0.004183135,0.01389964,0.001882404,0.0003030673,0.00009302297,0.000968551,0.0008494337,0.01529218],"genre_scores_gemma":[0.9869602,0.0007757106,0.003720211,0.0004234909,0.00003773878,0.00005021945,0.0008766546,0.0000593656,0.007096366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007332542,"threshold_uncertainty_score":0.02452976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008431370601874712,"score_gpt":0.2131070708959454,"score_spread":0.2046757002940706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}