{"id":"W4394761998","doi":"10.1093/bfgp/elae012","title":"Use of <i>in silico</i> approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies","year":2024,"lang":"en","type":"article","venue":"Briefings in Functional Genomics","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European and Developing Countries Clinical Trials Partnership; Grand Challenges Canada; Politechnika Warszawska; Narodowe Centrum Nauki; Government of Canada","keywords":"Polyclonal antibodies; Filoviridae; Biology; Monoclonal antibody; In silico; Epitope; Antibody; Virology; Antigen; Ebola virus; Marburg virus; Computational biology; Virus; Immunology; Biochemistry; Gene; Viral disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004469374,0.0001222452,0.0003047496,0.000386099,0.00002949364,0.00003282159,0.00003621966,0.00009831708,0.00004228585],"category_scores_gemma":[0.0001732862,0.000113662,0.00007847145,0.0003717844,0.0001695539,0.0001337468,0.00007236984,0.0002491394,0.000005648906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001189141,"about_ca_system_score_gemma":0.0001673294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009552649,"about_ca_topic_score_gemma":0.00003921818,"domain_scores_codex":[0.9988306,0.00003608298,0.000416955,0.0003286438,0.0002017272,0.0001860624],"domain_scores_gemma":[0.999413,0.0002716023,0.00005437667,0.0001611569,0.00005821447,0.00004163542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001291269,0.0005825826,0.1562926,0.002097247,0.0001896478,0.00006044488,0.0004492095,0.001630885,0.7399654,0.01173104,0.0005989088,0.08511068],"study_design_scores_gemma":[0.001021124,0.0003315007,0.3789978,0.00120836,0.0000830266,0.0002300598,0.0004051684,0.01415642,0.579381,0.001012875,0.02279165,0.0003809446],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951089,0.002835956,0.0004411569,0.0003207412,0.00006896583,0.0004265265,0.00004956903,0.00002105575,0.0007271231],"genre_scores_gemma":[0.9954334,0.001064805,0.003033996,0.00003839189,0.00007297251,0.00004327846,0.00001863111,0.00002477858,0.0002697721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2227052,"threshold_uncertainty_score":0.4635002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1229411132566951,"score_gpt":0.2823574264518451,"score_spread":0.15941631319515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}