{"id":"W4394770367","doi":"10.1016/j.ejso.2024.108324","title":"Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy","year":2024,"lang":"en","type":"article","venue":"European Journal of Surgical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé","keywords":"Medicine; Genetic testing; Mastectomy; Breast cancer; PALB2; CHEK2; Oncology; Cohort; Germline mutation; Cancer; Internal medicine; Mutation; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001048262,0.0001472488,0.0003758337,0.0001578768,0.00004242495,0.00002162116,0.000138272,0.00007457086,0.00001919129],"category_scores_gemma":[0.0002565561,0.0001203676,0.00005857988,0.0002991095,0.0001685366,0.00001278287,0.00008736773,0.0002346004,1.609177e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008379925,"about_ca_system_score_gemma":0.0003389912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007447418,"about_ca_topic_score_gemma":0.00004432098,"domain_scores_codex":[0.9979685,0.0007453826,0.0007269085,0.0002645299,0.0001280063,0.0001666765],"domain_scores_gemma":[0.9989,0.0002832162,0.0003892065,0.00009799263,0.0002256418,0.0001039279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001505746,0.0003166297,0.09663793,0.0001475484,0.0006990851,0.0008358151,0.004441394,0.01331009,0.3964018,0.000007200502,0.0006507392,0.485046],"study_design_scores_gemma":[0.00507908,0.005026935,0.9522324,0.001790051,0.0002379944,0.002309237,0.001511969,0.0006650066,0.02268237,0.00002324713,0.008017138,0.0004245532],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97973,0.01909013,0.00005648189,0.0004566587,0.0001379218,0.0001093672,0.0001038706,0.000004060956,0.000311571],"genre_scores_gemma":[0.9905835,0.005390293,0.003663951,0.00002479208,0.0002811668,0.000003085552,0.000004038006,0.00002871612,0.00002039306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8555945,"threshold_uncertainty_score":0.4908447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01762635410339769,"score_gpt":0.2927966315481019,"score_spread":0.2751702774447042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}