{"id":"W4394783163","doi":"10.1101/2024.04.10.588976","title":"Brilacidin, a novel antifungal agent against <i>Cryptococcus neoformans</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; RIKEN; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institutes of Health; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; International Development Research Centre; Canadian Institute for Advanced Research","keywords":"Cryptococcus neoformans; Antifungal; Cryptococcus; Microbiology; Cryptococcosis; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006824458,0.0003453306,0.0001766686,0.0002220525,0.0001746594,0.0001820615,0.0002270613,0.0002809209,0.001094988],"category_scores_gemma":[0.00005405153,0.00007006386,0.0001885823,0.0001196019,0.0001281102,0.0001701923,0.0001496424,0.0003794564,0.0003651639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845256,"about_ca_system_score_gemma":0.0001875117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003918279,"about_ca_topic_score_gemma":0.0004068528,"domain_scores_codex":[0.999958,0.000007437901,0.000003935717,0.000009199414,0.00001123475,0.00001019368],"domain_scores_gemma":[0.9999685,0.000002699078,0.000009028789,0.000002367456,0.000006409749,0.0000109032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002388172,0.00009475959,0.0001489859,0.0001738541,0.00000780047,0.0001781733,0.000009218369,0.0001338108,0.9907565,0.0001183162,0.0003446788,0.007795176],"study_design_scores_gemma":[0.0001355958,0.002703363,0.003519995,0.00004263648,0.00007110464,0.002156256,0.00002019613,0.0009941307,0.9656159,0.0000747142,0.02464596,0.00002006229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584674,0.02589298,0.003987157,0.0006396942,0.0003049781,0.0001742938,0.0007436849,0.0002651918,0.009524661],"genre_scores_gemma":[0.9792179,0.007166091,0.007548901,0.0004199062,0.00007729755,0.00005889081,0.0007902086,0.00001829082,0.004702545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094988,"threshold_uncertainty_score":0.003663123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963972681541657,"score_gpt":0.2440536724526769,"score_spread":0.2244139456372603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}