{"id":"W4394785048","doi":"10.1186/s13195-024-01440-9","title":"Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Capital Medical University; National Natural Science Foundation of China","keywords":"Biomarker; Geriatric psychiatry; Neurology; Disease; Medicine; Glycoprotein; Neuroscience; Internal medicine; Psychology; Biology; Psychiatry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001587269,0.0004128338,0.0006186863,0.00108012,0.000202167,0.0001706808,0.0004173935,0.0001816492,0.000826988],"category_scores_gemma":[0.000126801,0.0003351633,0.0004187196,0.001508895,0.0005409727,0.0005456949,0.0001288291,0.0005307706,0.0002276684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001100055,"about_ca_system_score_gemma":0.001260191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001580749,"about_ca_topic_score_gemma":0.00003742128,"domain_scores_codex":[0.9947295,0.00051837,0.0006249733,0.00106001,0.001626414,0.001440797],"domain_scores_gemma":[0.996418,0.0006169908,0.00005946755,0.001061567,0.0005113384,0.001332618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02758001,0.009989349,0.2265536,0.0006819111,0.1320571,0.004062441,0.003811714,0.000005832209,0.004085627,0.00176447,0.01479806,0.5746099],"study_design_scores_gemma":[0.02126164,0.01526257,0.8276166,0.002386199,0.004623263,0.00003858358,0.0007819833,0.01082326,0.08733519,0.01435266,0.01391095,0.001607123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7074032,0.2835882,0.00001081782,0.003842489,0.00008077847,0.004406174,0.0004027553,0.0001069828,0.0001586152],"genre_scores_gemma":[0.990912,0.00473198,0.0003043159,0.0002026673,0.000173871,0.003360328,0.0001216513,0.0001554905,0.00003770167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.601063,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.161463257305429,"score_gpt":0.4305890025102364,"score_spread":0.2691257452048073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}