{"id":"W4394785919","doi":"10.1016/j.isci.2026.115748","title":"Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment","year":2024,"lang":"en","type":"preprint","venue":"iScience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Huntingtin; Signal transducing adaptor protein; Cell biology; Motor protein; Biology; Neuroscience; Genetics; Gene; Microtubule; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002762326,0.000514281,0.0003856303,0.0002043721,0.000358526,0.0002575222,0.0007759198,0.0001348272,0.00008716656],"category_scores_gemma":[0.0005184103,0.0004573773,0.0001752403,0.0003710806,0.0005988061,0.00009188971,0.0009490908,0.0006293955,0.00003901629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008115916,"about_ca_system_score_gemma":0.0004079549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006460294,"about_ca_topic_score_gemma":0.00001150797,"domain_scores_codex":[0.9956757,0.000173127,0.0004477952,0.002175297,0.0009102511,0.0006178296],"domain_scores_gemma":[0.9985351,0.0002666555,0.0001538647,0.0006112912,0.00005492292,0.0003781938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001391509,0.000100092,0.0001975151,0.0001001483,0.000004481334,0.00005000903,0.0004415666,0.00008678473,0.9939476,0.0001345992,0.001175085,0.00374816],"study_design_scores_gemma":[0.0001746782,0.0001192835,0.002789506,0.000330402,0.00007144652,0.00003318017,0.00008114726,0.004155827,0.9848461,0.0004790798,0.006262277,0.0006570635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901477,0.002929962,0.0001785993,0.001594481,0.001420717,0.00114291,0.001280024,0.0002223958,0.001083199],"genre_scores_gemma":[0.9921784,0.0003538011,0.0008683624,0.0009965098,0.0001523526,0.0003894462,0.00001631501,0.00005616664,0.004988668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009101534,"threshold_uncertainty_score":0.9997878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07378075102629401,"score_gpt":0.3029334966452519,"score_spread":0.2291527456189579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}