{"id":"W4394787042","doi":"10.1016/j.mcpro.2024.100767","title":"Replisome Proximal Protein Associations and Dynamic Proteomic Changes at Stalled Replication Forks","year":2024,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Replisome; Pre-replication complex; Control of chromosome duplication; Biology; Origin recognition complex; DNA replication; DNA re-replication; Eukaryotic DNA replication; Helicase; Genetics; Cell biology; Chromatin; Genome instability; DNA repair; Replication factor C; DNA replication factor CDT1; Computational biology; DNA damage; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009044868,0.0002715761,0.0002043426,0.0004219625,0.0002550067,0.0003070201,0.0001747445,0.0002418696,0.001435695],"category_scores_gemma":[0.0001144012,0.0001839569,0.0001699092,0.0002502851,0.0002012145,0.000248605,0.00031623,0.0002849691,0.0004802984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001930743,"about_ca_system_score_gemma":0.0001175913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007441417,"about_ca_topic_score_gemma":0.001117811,"domain_scores_codex":[0.9999158,0.000006369633,0.000003567991,0.00003274926,0.00002037082,0.00002102203],"domain_scores_gemma":[0.9999162,0.000008648003,0.00002524589,0.000006281178,0.00001563135,0.00002801306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031094,0.000005894419,0.000922187,0.00002786788,0.000009279557,0.00005566556,0.00002542988,0.00002559689,0.9982234,0.00003036104,0.00001726301,0.0005540778],"study_design_scores_gemma":[0.000009033883,0.0001532329,0.1598852,0.00001286808,0.00004836036,0.0006724395,0.000237881,0.001147172,0.8349327,0.0001570246,0.002727839,0.00001622829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950015,0.001546365,0.002015437,0.00004983856,0.000009927677,0.000007231802,0.0004848861,0.00003510164,0.0008495983],"genre_scores_gemma":[0.9941456,0.0008557207,0.001413249,0.00004641871,0.00000745656,0.00001622817,0.0007419048,0.00001606527,0.002757273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435695,"threshold_uncertainty_score":0.004802883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005928285103690113,"score_gpt":0.2329652305864409,"score_spread":0.2270369454827508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}