{"id":"W4394787042","doi":"10.1016/j.mcpro.2024.100767","title":"Replisome Proximal Protein Associations and Dynamic Proteomic Changes at Stalled Replication Forks","year":2024,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"Replisome; Pre-replication complex; Control of chromosome duplication; Biology; Origin recognition complex; DNA replication; DNA re-replication; Eukaryotic DNA replication; Helicase; Genetics; Cell biology; Chromatin; Genome instability; DNA repair; Replication factor C; DNA replication factor CDT1; Computational biology; DNA damage; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004382048,0.0003136284,0.0002391888,0.00009696014,0.0002746214,0.0001164974,0.0001839964,0.0004773879,0.000007937544],"category_scores_gemma":[0.0001277793,0.0002944866,0.0001319667,0.000175527,0.0001428012,0.00000837771,0.0003607463,0.0003083168,0.00001981857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001236254,"about_ca_system_score_gemma":0.00008798549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001203174,"about_ca_topic_score_gemma":0.00002339108,"domain_scores_codex":[0.9980007,0.000108961,0.0003039962,0.000977973,0.0002078383,0.0004004816],"domain_scores_gemma":[0.9989682,0.000006282879,0.0001297609,0.0007005003,0.00009476661,0.0001005116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004974736,0.00004287695,0.00006579663,0.0001483919,0.0002205196,0.00002462977,0.0001092247,0.00001132661,0.9969819,0.0003835344,0.0001352826,0.001826837],"study_design_scores_gemma":[0.0003986212,0.0002765785,0.0001252225,0.00008119836,0.00006996173,0.00003192488,0.00002631004,0.001884892,0.9899499,0.000458546,0.0063239,0.0003729412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775804,0.009510021,0.007129095,0.00217204,0.0001162854,0.002911427,0.00007054216,0.0001216288,0.0003885805],"genre_scores_gemma":[0.9865723,0.0005165517,0.005755594,0.0001347791,0.0001100914,0.0008880594,0.0005554734,0.000102402,0.005364736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008993469,"threshold_uncertainty_score":0.9999507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005928285103690113,"score_gpt":0.2329652305864409,"score_spread":0.2270369454827508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}