{"id":"W4394792404","doi":"10.1172/jci168536","title":"Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Veterinärmedizinische Universität Wien; St. Jude Children's Research Hospital; Academy of Finland; Austrian Science Fund; European Commission; Syöpäjärjestöt; Lymphoma Research Foundation","keywords":"T-cell receptor; T cell; Biology; STAT5; Cancer research; T-cell leukemia; Cell biology; ZAP70; Leukemia; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001763735,0.0002617871,0.0007654849,0.0003090017,0.00008890254,0.0001591821,0.000169733,0.0004157174,0.0001309704],"category_scores_gemma":[0.001779546,0.0001926689,0.0003109803,0.0004036037,0.0004421092,0.000571535,0.00008257241,0.001547033,0.0001021495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007558707,"about_ca_system_score_gemma":0.004084508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001039671,"about_ca_topic_score_gemma":4.199527e-7,"domain_scores_codex":[0.9964145,0.0003240031,0.001644848,0.0003912644,0.0008864215,0.0003389037],"domain_scores_gemma":[0.9944059,0.003371107,0.0006342955,0.0002073322,0.0005783801,0.0008030144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004245785,0.0003390667,0.0084211,0.001478231,0.001178164,0.002403075,0.002864238,0.0004769711,0.9132621,0.0002912704,0.05285779,0.01218227],"study_design_scores_gemma":[0.03954191,0.01513657,0.05183221,0.01168523,0.007731708,0.007484004,0.004213625,0.1521319,0.6532931,0.01434987,0.04042199,0.00217789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918238,0.001238543,0.002502755,0.002354048,0.001110518,0.0002572198,0.00001950943,0.00004651307,0.0006470775],"genre_scores_gemma":[0.973704,0.001120218,0.02097006,0.0007655168,0.001852087,0.000004704531,0.00002581777,0.00006173256,0.001495846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2599689,"threshold_uncertainty_score":0.7856809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03173571434599548,"score_gpt":0.3522638004065625,"score_spread":0.320528086060567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}