{"id":"W4394792404","doi":"10.1172/jci168536","title":"Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Veterinärmedizinische Universität Wien; St. Jude Children's Research Hospital; Academy of Finland; Austrian Science Fund; European Commission; Syöpäjärjestöt; Lymphoma Research Foundation","keywords":"T-cell receptor; T cell; Biology; STAT5; Cancer research; T-cell leukemia; Cell biology; ZAP70; Leukemia; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115182,0.0002369511,0.0001887235,0.0002402675,0.0001463946,0.0003660113,0.000117841,0.0002151087,0.001647971],"category_scores_gemma":[0.00008325149,0.0001194662,0.0002001905,0.0002228823,0.000284269,0.0001236221,0.0001971805,0.0007230056,0.0003859218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004084465,"about_ca_system_score_gemma":0.0001963181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005678153,"about_ca_topic_score_gemma":0.001157051,"domain_scores_codex":[0.9997781,0.00003056598,0.00002164414,0.00004599704,0.00006572141,0.00005795665],"domain_scores_gemma":[0.9999319,0.00001122706,0.00001922753,0.000008746792,0.000004337466,0.00002460977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001120568,0.00002954121,0.0008031412,0.00002980862,0.000006142826,0.00009104871,0.00001688748,0.0001196972,0.9968554,0.0001611005,0.00009046474,0.001684674],"study_design_scores_gemma":[0.00003540693,0.0005063394,0.01235154,0.0000102422,0.00004085468,0.001036717,0.0001015433,0.00165267,0.9779749,0.0001679678,0.006114517,0.000007392408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958363,0.000642086,0.001579278,0.0000777863,0.00001996598,0.00002391796,0.0006369306,0.0001381804,0.001045569],"genre_scores_gemma":[0.9969792,0.0003372183,0.0008410443,0.00006308108,0.000004208023,0.00001767154,0.0006112394,0.00002042468,0.001125799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647971,"threshold_uncertainty_score":0.005513012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03173571434599548,"score_gpt":0.3522638004065625,"score_spread":0.320528086060567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}