{"id":"W4394797601","doi":"10.1177/02698811241246857","title":"Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy- <i>N,N</i> -dimethyltryptamine benzoate) in healthy participants","year":2024,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; NIHR Maudsley Biomedical Research Centre; Victoria General Hospital Foundation; Servier; National Institute for Health and Care Research; H. Lundbeck A/S; National Institute of Mental Health; LivaNova; Canadian Institutes of Health Research; Sunovion; Wellcome Trust; Michael Smith Health Research BC; South London and Maudsley NHS Foundation Trust; Eli Lilly and Company; National Alliance for Research on Schizophrenia and Depression; King's College London","keywords":"Pharmacokinetics; Tolerability; Placebo; Pharmacodynamics; Nasal administration; Adverse effect; Pharmacology; Vomiting; Medicine; Nausea; Anesthesia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008904308,0.001369816,0.002029476,0.0002727562,0.0003830491,0.0005780769,0.0007488396,0.001336928,0.00558],"category_scores_gemma":[0.00112309,0.0005863914,0.0005805649,0.0001936595,0.0007358673,0.0006824193,0.0002203514,0.001645101,0.0008780851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004835339,"about_ca_system_score_gemma":0.0008821423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006114155,"about_ca_topic_score_gemma":0.001394136,"domain_scores_codex":[0.999762,0.00008930163,0.00001355986,0.00006440964,0.00002745349,0.00004324964],"domain_scores_gemma":[0.9992945,0.0001561001,0.0001827983,0.0000535172,0.00005615544,0.0002568235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9303967,0.01995637,0.001162762,0.0004815883,0.0003481822,0.00007754961,0.000091285,0.0002634202,0.02613841,0.00006599594,0.0007105973,0.02030716],"study_design_scores_gemma":[0.6563281,0.3316448,0.00741173,0.00002328286,0.0002456541,0.00009940365,0.00003157167,0.0006287072,0.002820031,0.00009125395,0.0006589929,0.00001650728],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954194,0.001215547,0.0003655855,0.0001554597,0.0001050286,0.001434491,0.0004673171,0.00009727295,0.0007399458],"genre_scores_gemma":[0.9924852,0.0009300755,0.001241716,0.00055683,0.0001925785,0.001919014,0.0006638201,0.00001992959,0.001990702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00558,"threshold_uncertainty_score":0.01866698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05151592979433455,"score_gpt":0.4513576548826305,"score_spread":0.399841725088296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}