{"id":"W4394797601","doi":"10.1177/02698811241246857","title":"Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy- <i>N,N</i> -dimethyltryptamine benzoate) in healthy participants","year":2024,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; NIHR Maudsley Biomedical Research Centre; Victoria General Hospital Foundation; Servier; National Institute for Health and Care Research; H. Lundbeck A/S; National Institute of Mental Health; LivaNova; Canadian Institutes of Health Research; Sunovion; Wellcome Trust; Michael Smith Health Research BC; South London and Maudsley NHS Foundation Trust; Eli Lilly and Company; National Alliance for Research on Schizophrenia and Depression; King's College London","keywords":"Pharmacokinetics; Tolerability; Placebo; Pharmacodynamics; Nasal administration; Adverse effect; Pharmacology; Vomiting; Medicine; Nausea; Anesthesia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006345914,0.0003884591,0.001547116,0.0007777546,0.00008844681,0.00003071794,0.0003779023,0.0001519828,0.0002784622],"category_scores_gemma":[0.0002811561,0.0002605208,0.0002862071,0.0006767933,0.0002924676,0.00007772072,0.00006910967,0.0007447599,0.000008697672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000962383,"about_ca_system_score_gemma":0.000125601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000039144,"about_ca_topic_score_gemma":0.00002797551,"domain_scores_codex":[0.9940606,0.002221414,0.002149662,0.0004338054,0.0004621174,0.0006724249],"domain_scores_gemma":[0.9935503,0.005029828,0.0006986377,0.0002406039,0.0002140572,0.0002665977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7963931,0.003283149,0.0002383268,0.0002271296,0.002200343,0.0001536694,0.006617048,0.0006777412,0.1421623,0.0002113025,0.01293707,0.03489881],"study_design_scores_gemma":[0.9099084,0.05402569,0.0008201015,0.0005186364,0.002049962,0.0001424945,0.001458143,0.00224083,0.01870557,0.0009553199,0.008619945,0.0005548801],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732687,0.008110925,0.0002762894,0.004924753,0.01098416,0.001841978,0.00007662989,0.00001541516,0.0005011819],"genre_scores_gemma":[0.996637,0.001237793,0.0001185232,0.00103221,0.0007941013,0.0001001842,0.00000241097,0.00004657571,0.00003118137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1234567,"threshold_uncertainty_score":0.9999847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05151592979433455,"score_gpt":0.4513576548826305,"score_spread":0.399841725088296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}