{"id":"W4394804648","doi":"10.1101/2024.04.12.589199","title":"Unleashing the Immune Arsenal: Development of Broad-spectrum Multiepitope Bluetongue Vaccine Targeting Conserved T Cell Epitopes of Structural Proteins","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Vector-Borne Animal Diseases","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Faculty of Medicine, Dalhousie University; Canadian Institutes of Health Research; Dalhousie University; Canada Research Chairs","keywords":"Epitope; Immunogenicity; Virology; Biology; Antigen; Immune system; Innate immune system; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200486,0.0004493107,0.0003959751,0.000148126,0.0002019033,0.0005749111,0.0003502401,0.000443285,0.0009520412],"category_scores_gemma":[0.0001857834,0.0002487878,0.000480086,0.0001292856,0.000181556,0.0004630476,0.0002970947,0.0006694522,0.000253288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250625,"about_ca_system_score_gemma":0.0005471965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001023278,"about_ca_topic_score_gemma":0.001331816,"domain_scores_codex":[0.9999394,0.00001119379,0.000002193396,0.0000129284,0.00002007202,0.00001428257],"domain_scores_gemma":[0.9999672,0.00001091399,0.000006606048,0.000002384579,0.000005329357,0.00000757065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004213791,0.0003483119,0.006282472,0.0006263626,0.0001383044,0.000765978,0.00009844416,0.4671434,0.4619633,0.006339086,0.001598392,0.05427455],"study_design_scores_gemma":[0.00008656397,0.0004469344,0.001032399,0.00002832959,0.00008950366,0.0002357855,0.00006891182,0.9174511,0.07297321,0.001932879,0.005634263,0.00002016241],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8605564,0.003195476,0.1264145,0.0009061152,0.0001140377,0.00007718053,0.0003627987,0.001117644,0.007255814],"genre_scores_gemma":[0.9162409,0.002220279,0.07898281,0.0002780769,0.00001890157,0.00006599604,0.000713085,0.0001321421,0.0013477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023278,"threshold_uncertainty_score":0.003184855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323971038513964,"score_gpt":0.2035518467328477,"score_spread":0.190312136347708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}