{"id":"W4394812519","doi":"10.21203/rs.3.rs-4238470/v1","title":"Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"MSH6; Colonoscopy; PMS2; Medicine; Lynch syndrome; MLH1; Colorectal cancer; MSH2; Internal medicine; Adenoma; Incidence (geometry); Malignancy; Gastroenterology; Oncology; Cancer; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00040652,0.0001877664,0.0001498111,0.001291664,0.0001742698,0.0002765312,0.000232477,0.0002951785,0.002125186],"category_scores_gemma":[0.00171554,0.0002137287,0.0003449227,0.0005340233,0.0002473322,0.0001830719,0.0003152291,0.0002446943,0.00009494648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106124,"about_ca_system_score_gemma":0.0002156449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003077101,"about_ca_topic_score_gemma":0.003380252,"domain_scores_codex":[0.9997815,0.00004355767,0.00002890667,0.00006869451,0.00004010413,0.00003717166],"domain_scores_gemma":[0.9981897,0.0005748486,0.000770017,0.0001911288,0.00008793271,0.0001862933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000367872,0.00001336461,0.9955041,0.000008006039,0.00003923599,0.0001043924,0.00003731189,0.0001214121,0.002269992,0.00003728635,0.00002246904,0.001474602],"study_design_scores_gemma":[0.000008215063,0.0001314148,0.9983214,0.000001165604,0.0000271911,0.0005360283,0.00004633888,0.0003342938,0.0005084984,0.00003603246,0.00004718138,0.000002404294],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996186,0.00002804466,0.0001125879,0.000006348041,4.080073e-7,0.000002834699,0.000125282,0.000005513832,0.0001003479],"genre_scores_gemma":[0.9995835,0.00001503313,0.0001665435,0.000002401702,7.685744e-7,0.000002255782,0.0001736117,9.162314e-7,0.00005495001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003077101,"threshold_uncertainty_score":0.007109404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1348540565637838,"score_gpt":0.4057999326781792,"score_spread":0.2709458761143954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}