{"id":"W4394812727","doi":"10.1002/pros.24707","title":"Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models","year":2024,"lang":"en","type":"article","venue":"The Prostate","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Congressionally Directed Medical Research Programs; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Genentech; European Association for Cancer Research; MacroGenics; Bristol-Myers Squibb; Foghorn Therapeutics; U.S. Department of Defense; Sanofi; Pfizer; Associazione Italiana per la Ricerca sul Cancro; Pharmaceutical Research and Manufacturers of America Foundation; Gilead Sciences","keywords":"Pharmacology; Prostate cancer; Pharmacokinetics; Pharmacodynamics; In vivo; Chemistry; Bioavailability; Medicine; Cancer; Cancer research; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032014,0.00008661702,0.00009683411,0.00002474052,0.00002529594,0.00001405016,0.0001105551,0.00004888297,0.000002452884],"category_scores_gemma":[0.00002310549,0.0000485494,0.00003884752,0.0001029984,0.0001792494,0.000007099825,0.0001145507,0.0000859589,2.495287e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005011358,"about_ca_system_score_gemma":0.00004044333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001125723,"about_ca_topic_score_gemma":0.000002765703,"domain_scores_codex":[0.9992918,0.00007675299,0.0002705298,0.0001662564,0.00009470709,0.00009998059],"domain_scores_gemma":[0.9997054,0.00001201498,0.00007702242,0.0001424286,0.00004412647,0.00001905299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007718952,0.00001392126,0.0005074231,0.0001253411,0.00001870505,1.271386e-7,0.0003546023,0.0002373293,0.9955704,0.00002143123,0.000005055134,0.003068452],"study_design_scores_gemma":[0.0002247561,0.00004987144,0.001914493,0.00007690012,0.00002140355,8.693407e-7,0.00001501965,0.01944886,0.977505,0.000433408,0.0002477086,0.00006167551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931319,0.005900101,0.00008210571,0.0003112486,0.0001415258,0.0003578629,0.00004747165,0.000004524016,0.00002324703],"genre_scores_gemma":[0.9976674,0.002067247,0.00002824685,0.00002255138,0.00005160614,0.00001755185,0.00002676432,0.00001304021,0.00010563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01921153,"threshold_uncertainty_score":0.1979787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245780770353147,"score_gpt":0.2903459137647099,"score_spread":0.2678881060611784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}