{"id":"W4394812727","doi":"10.1002/pros.24707","title":"Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models","year":2024,"lang":"en","type":"article","venue":"The Prostate","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Congressionally Directed Medical Research Programs; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Genentech; European Association for Cancer Research; MacroGenics; Bristol-Myers Squibb; Foghorn Therapeutics; U.S. Department of Defense; Sanofi; Pfizer; Associazione Italiana per la Ricerca sul Cancro; Pharmaceutical Research and Manufacturers of America Foundation; Gilead Sciences","keywords":"Pharmacology; Prostate cancer; Pharmacokinetics; Pharmacodynamics; In vivo; Chemistry; Bioavailability; Medicine; Cancer; Cancer research; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010354,0.0004633876,0.0003101359,0.0002887619,0.0001560453,0.0002333204,0.000301401,0.0002569829,0.001147421],"category_scores_gemma":[0.0002387419,0.0001650991,0.0003058576,0.0002430734,0.0001808373,0.0002024963,0.00009079148,0.0006116626,0.0004501368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005511393,"about_ca_system_score_gemma":0.0003841937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324072,"about_ca_topic_score_gemma":0.001871485,"domain_scores_codex":[0.9998981,0.00001640625,0.000008807651,0.00001803136,0.00004070597,0.00001790284],"domain_scores_gemma":[0.9998381,0.00002836886,0.00004822826,0.00002146125,0.00003400917,0.00002978054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000411387,0.0001399626,0.0003306459,0.00009578853,0.0000271137,0.00004086081,0.00001865273,0.001033715,0.9934819,0.00006327529,0.0002084045,0.004148188],"study_design_scores_gemma":[0.00004595982,0.001798925,0.001911335,0.000006618545,0.00003829331,0.0001935872,0.00001004612,0.001821321,0.9911525,0.00002942837,0.002983054,0.000008891628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733579,0.006317523,0.01318189,0.0002189925,0.00005050445,0.0002545164,0.00368946,0.000283053,0.0026462],"genre_scores_gemma":[0.9793019,0.003216393,0.008144535,0.00006074328,0.0000194968,0.0001407942,0.005117435,0.00006061527,0.0039381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324072,"threshold_uncertainty_score":0.003998756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245780770353147,"score_gpt":0.2903459137647099,"score_spread":0.2678881060611784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}