{"id":"W4394817385","doi":"10.1158/1538-7445.fcs2023-p28","title":"Abstract P28: Comprehensive Molecular Phenotyping of <i>ARID1A</i>-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"ARID1A; Cancer research; Epigenetics; Biology; Epigenomics; Chromatin; Enhancer; Cancer; Bromodomain; Genetics; Gene; DNA methylation; Gene expression; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006623829,0.000213324,0.0004506393,0.0004227998,0.0001540063,0.00009428923,0.0001455468,0.00009849704,0.0005083648],"category_scores_gemma":[0.0000205333,0.0001866033,0.0001349308,0.0005508382,0.0003179457,0.00006342242,0.00009821141,0.0005748923,0.000006466009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184682,"about_ca_system_score_gemma":0.0009343417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002013546,"about_ca_topic_score_gemma":0.00004491046,"domain_scores_codex":[0.9976916,0.0000949081,0.0003735553,0.0005738293,0.0006523511,0.0006137359],"domain_scores_gemma":[0.9985828,0.0001949306,0.00007442373,0.0003977928,0.0005276965,0.0002223443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002654589,0.00005175775,0.000225567,0.001366056,0.0003395961,0.0002260413,0.001903304,0.00007518235,0.6882278,0.004390818,0.0001684718,0.30276],"study_design_scores_gemma":[0.008389607,0.003308325,0.02220656,0.02165579,0.001266227,0.0004956034,0.02920007,0.004155891,0.6359607,0.02401104,0.2469034,0.002446775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8072966,0.1891701,0.0002885749,0.001679098,0.0002530126,0.000793721,0.0000615416,0.0000540135,0.0004033374],"genre_scores_gemma":[0.9786724,0.0196429,0.0001803715,0.0003699573,0.000228149,0.0003381359,0.00001022328,0.00007073551,0.0004870893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3003132,"threshold_uncertainty_score":0.7609462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1858655612336353,"score_gpt":0.4239057772134555,"score_spread":0.2380402159798202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}