{"id":"W4394817385","doi":"10.1158/1538-7445.fcs2023-p28","title":"Abstract P28: Comprehensive Molecular Phenotyping of <i>ARID1A</i>-deficient Gastric Cancer Reveals Pervasive Epigenomic Reprogramming and Therapeutic Opportunities","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"ARID1A; Cancer research; Epigenetics; Biology; Epigenomics; Chromatin; Enhancer; Cancer; Bromodomain; Genetics; Gene; DNA methylation; Gene expression; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137813,0.0002089869,0.0002380698,0.0002475086,0.0001271688,0.0002423065,0.000153461,0.0001694625,0.001910768],"category_scores_gemma":[0.00009799627,0.0001421198,0.0002365836,0.0002007946,0.0001894898,0.0001005375,0.0002263547,0.0003445584,0.0005948293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687549,"about_ca_system_score_gemma":0.0001415195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006488236,"about_ca_topic_score_gemma":0.0008029122,"domain_scores_codex":[0.9999317,0.00000624259,0.000005707224,0.00002584843,0.00001811643,0.00001239842],"domain_scores_gemma":[0.9999238,0.000009126702,0.00002155959,0.00001248271,0.000009901832,0.00002309162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002758614,0.00001390868,0.01041379,0.00004513306,0.00002086061,0.0002469033,0.00003289825,0.0001791437,0.9848675,0.00006666221,0.0002763451,0.003560901],"study_design_scores_gemma":[0.00005506485,0.0005933086,0.3226812,0.00001610316,0.0001192602,0.006328649,0.0002652666,0.004164487,0.6555737,0.0003418781,0.009842352,0.00001867506],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924927,0.000389243,0.002353404,0.00008649898,0.000006943448,0.0000318856,0.003432027,0.0001505074,0.001056614],"genre_scores_gemma":[0.9934349,0.000308017,0.001619625,0.00006543398,0.000004109547,0.00003771552,0.00286956,0.00005374389,0.001606765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001910768,"threshold_uncertainty_score":0.006392181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1858655612336353,"score_gpt":0.4239057772134555,"score_spread":0.2380402159798202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}