{"id":"W4394819260","doi":"10.1002/ddr.22181","title":"Single and multiple inhibitors of the biosynthesis of 5‐, 12‐, 15‐lipoxygenase products derived from cinnamyl‐3,4‐dihydroxy‐α‐cyanocinnamate: Synthesis and structure–activity relationship","year":2024,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Canada Foundation for Innovation; Université de Moncton","keywords":"Biosynthesis; Chemistry; Arachidonate 5-lipoxygenase; Stereochemistry; Docking (animal); Moiety; Structure–activity relationship; Zileuton; Biochemistry; Caffeic acid; Enzyme; In vitro; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769112,0.0005419238,0.0003663286,0.000378309,0.0001183034,0.0002761384,0.0002772493,0.0002581238,0.001690113],"category_scores_gemma":[0.00009748552,0.0001469509,0.0003245853,0.0002896622,0.0001626514,0.0003041362,0.0002225281,0.0006619261,0.0003076671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335935,"about_ca_system_score_gemma":0.0003899688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008321453,"about_ca_topic_score_gemma":0.002965845,"domain_scores_codex":[0.9999282,0.000006525998,0.000007306729,0.00001470652,0.00001775143,0.00002546493],"domain_scores_gemma":[0.9999454,0.00000550691,0.00001395926,0.000005648023,0.000008132904,0.00002135676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005000797,0.0002121862,0.0002417426,0.0002239751,0.00003756105,0.0001017312,0.00001555211,0.0004629725,0.9857495,0.0002251332,0.0001355085,0.01209389],"study_design_scores_gemma":[0.0003090433,0.003760966,0.00336955,0.00002279739,0.0001378793,0.0003135061,0.00001676727,0.001256088,0.9816691,0.00007981194,0.009045266,0.00001920888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537112,0.03401144,0.006213203,0.0002331927,0.00009388714,0.0002570407,0.001069708,0.0001848752,0.004225487],"genre_scores_gemma":[0.9764203,0.01412895,0.004333125,0.0001038316,0.00002811291,0.0001169091,0.001327832,0.00001981383,0.003521059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690113,"threshold_uncertainty_score":0.005654037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03028741414213436,"score_gpt":0.2577596863831631,"score_spread":0.2274722722410287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}