{"id":"W4394819260","doi":"10.1002/ddr.22181","title":"Single and multiple inhibitors of the biosynthesis of 5‐, 12‐, 15‐lipoxygenase products derived from cinnamyl‐3,4‐dihydroxy‐α‐cyanocinnamate: Synthesis and structure–activity relationship","year":2024,"lang":"en","type":"article","venue":"Drug Development Research","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Canada Foundation for Innovation; Université de Moncton","keywords":"Biosynthesis; Chemistry; Arachidonate 5-lipoxygenase; Stereochemistry; Docking (animal); Moiety; Structure–activity relationship; Zileuton; Biochemistry; Caffeic acid; Enzyme; In vitro; Arachidonic acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000790532,0.0002118047,0.0002329439,0.0001215197,0.0002310065,0.00005296036,0.0002496459,0.0002002796,0.00001813201],"category_scores_gemma":[0.001777273,0.0001545157,0.0000530654,0.0003190717,0.0004436556,0.00001451359,0.0003921706,0.000223724,0.000001471348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003613189,"about_ca_system_score_gemma":0.0002981066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001380208,"about_ca_topic_score_gemma":0.0001660932,"domain_scores_codex":[0.9980519,0.0002992367,0.0003235093,0.0005989725,0.0004193828,0.0003069756],"domain_scores_gemma":[0.9986174,0.0006521724,0.00009342867,0.0003967961,0.000149331,0.00009088175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001233011,0.00006969427,0.0178602,0.0003542451,0.0001211364,0.000002811816,0.0003692067,0.000001942894,0.9741977,0.00000511734,0.0004981853,0.006396408],"study_design_scores_gemma":[0.0001119954,0.00001890128,0.04346413,0.0002762297,0.00002444987,0.000007288511,0.0001444624,0.00007801002,0.9536714,0.00004034206,0.001987387,0.0001753958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996936,0.001624004,0.000008192264,0.0006716362,0.00007391266,0.0002995899,0.0002654783,0.00001376429,0.0001073893],"genre_scores_gemma":[0.9986085,0.0001401123,0.0007758149,0.000007472552,0.00007977104,0.00001515182,0.00005117103,0.00002259435,0.0002994447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02560393,"threshold_uncertainty_score":0.6300969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03028741414213436,"score_gpt":0.2577596863831631,"score_spread":0.2274722722410287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}