{"id":"W4394841173","doi":"10.1371/journal.pone.0298065","title":"Alfaxalone is an effective anesthetic for the electrophysiological study of anoxia-tolerance mechanisms in western painted turtle pyramidal neurons","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Electrophysiology; Anesthetic; Anesthesia; Patch clamp; Sedation; Neuroscience; Pharmacology; Medicine; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001733548,0.0003553971,0.0002588136,0.0001613977,0.0002094004,0.0001560934,0.0002541024,0.0003180662,0.001064185],"category_scores_gemma":[0.0001789186,0.0001112004,0.0002425402,0.0001207585,0.0001863386,0.0003972974,0.0001437799,0.0004302847,0.0002608564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00014536,"about_ca_system_score_gemma":0.0001814485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005823699,"about_ca_topic_score_gemma":0.001125141,"domain_scores_codex":[0.9998859,0.00001529796,0.00001931826,0.00002766084,0.00003329266,0.00001851041],"domain_scores_gemma":[0.9998872,0.00001375771,0.00003723407,0.00001065227,0.00002898902,0.00002223204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107286,0.00002756814,0.0001111526,0.00005733591,0.000004672937,0.00006974961,0.00001571769,0.00002753737,0.9981135,0.00002435531,0.00003715218,0.001403891],"study_design_scores_gemma":[0.00003682477,0.00154938,0.008017104,0.00001854774,0.00004109443,0.0005861407,0.00004864444,0.0006771816,0.9869351,0.00004349308,0.002038807,0.000007766162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868705,0.002689095,0.007960614,0.0002376626,0.000097451,0.0001465781,0.0003913187,0.0001456755,0.00146126],"genre_scores_gemma":[0.9725108,0.003467675,0.01908747,0.0001925885,0.00005165669,0.0003510808,0.0008358247,0.00004308869,0.003459785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064185,"threshold_uncertainty_score":0.003560066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03093805737493943,"score_gpt":0.2358365611855629,"score_spread":0.2048985038106234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}