{"id":"W4394841468","doi":"10.1073/pnas.2315018121","title":"Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto; McGill University; University Health Network","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; McGill University","keywords":"Ubiquitin ligase; Ubiquitin; Heterotrimeric G protein; DNA ligase; Cullin; Ubiquitin-Protein Ligases; Chemistry; Substrate (aquarium); Stereochemistry; Biophysics; Biochemistry; Biology; Receptor; G protein; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000797488,0.0001793574,0.0001963318,0.0001979274,0.0004793747,0.0006045999,0.0004031622,0.0003419701,0.001904428],"category_scores_gemma":[0.0001468363,0.0002605248,0.0001912786,0.0001714965,0.0003409164,0.0003818197,0.0002313939,0.0005534998,0.0004101091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001472462,"about_ca_system_score_gemma":0.0003070248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005105144,"about_ca_topic_score_gemma":0.003129397,"domain_scores_codex":[0.9999206,0.000005426515,0.000003942978,0.00003075218,0.00002014588,0.00001910734],"domain_scores_gemma":[0.9999083,0.00000819928,0.00001977402,0.000007711493,0.000009341449,0.00004670515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008611052,0.0002773963,0.01091899,0.0001550101,0.0001676318,0.001076251,0.0005351095,0.03511986,0.9353742,0.003287335,0.002631418,0.009595665],"study_design_scores_gemma":[0.0003036488,0.0007963352,0.1151713,0.00007375949,0.000143391,0.001673416,0.0008097949,0.4920185,0.368829,0.00306201,0.01691245,0.0002064472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950145,0.0004418923,0.002203162,0.0002071888,0.00001229076,0.000009459773,0.000224979,0.0001461487,0.001740306],"genre_scores_gemma":[0.9973283,0.0001672005,0.001227215,0.00006261795,0.000002653319,0.000006237606,0.0004603946,0.00002082153,0.0007244982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005105144,"threshold_uncertainty_score":0.01068348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02797242462952803,"score_gpt":0.2980915372063078,"score_spread":0.2701191125767798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}