{"id":"W4394851164","doi":"10.1016/j.bpsc.2024.04.005","title":"Leptin’s Inverse Association With Brain Morphology and Depressive Symptoms: A Discovery and Confirmatory Study Across 2 Independent Samples","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Japan Science and Technology Agency; National Institutes of Health; University of Oklahoma; William K. Warren Foundation","keywords":"Leptin; Insula; Association (psychology); Major depressive disorder; Psychology; Internal medicine; Neuroimaging; Neuroscience; Medicine; Endocrinology; Clinical psychology; Cognition; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006356685,0.0009143005,0.00073544,0.0006907469,0.001416815,0.0007452676,0.0009509106,0.0007447713,0.001261173],"category_scores_gemma":[0.006952484,0.0009111424,0.001061308,0.0005818756,0.00110568,0.0005114602,0.001191445,0.001138612,0.0004880895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000461164,"about_ca_system_score_gemma":0.000750752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005997162,"about_ca_topic_score_gemma":0.01059681,"domain_scores_codex":[0.9967732,0.001679344,0.0002483822,0.0006096967,0.0004514874,0.0002378502],"domain_scores_gemma":[0.9955035,0.001278591,0.0007361542,0.00127425,0.000783018,0.0004245107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002687613,0.00102883,0.970345,0.00006852054,0.0007127122,0.0005123308,0.002950212,0.00009259783,0.01579862,0.000120596,0.0003425576,0.005340496],"study_design_scores_gemma":[0.0003423227,0.001811053,0.9939731,0.000009187255,0.0002501032,0.0007811059,0.000745077,0.0002900143,0.001185762,0.0000449349,0.0005512808,0.00001606817],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989372,0.00006914145,0.0005719419,0.00002768578,0.000006713722,0.0001006087,0.0001265487,0.000007408882,0.0001527793],"genre_scores_gemma":[0.9975936,0.00003792049,0.001361734,0.00005219591,0.00001096793,0.0001433945,0.0005557108,0.00001058157,0.0002338741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006356685,"threshold_uncertainty_score":0.03361779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027669167565771,"score_gpt":0.3120691745819029,"score_spread":0.2717924829062452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}