{"id":"W4394852260","doi":"10.1101/2024.04.12.589110","title":"Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Mitochondrion; Bioenergetics; Cancer research; Cancer cell; Cell biology; Oxidative phosphorylation; Myeloid leukemia; Biology; Chemistry; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003271537,0.000808012,0.0006399511,0.0002948056,0.0001809607,0.0003736503,0.001138517,0.001019321,0.00009300555],"category_scores_gemma":[0.0001422246,0.0008398105,0.0004054922,0.0005128132,0.0001541713,0.000007399146,0.001917998,0.00100508,0.0006043424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406179,"about_ca_system_score_gemma":0.001484842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004732737,"about_ca_topic_score_gemma":0.00000600846,"domain_scores_codex":[0.9958568,0.0001182823,0.0005555694,0.001950607,0.000564756,0.0009539421],"domain_scores_gemma":[0.9965996,0.00002416303,0.0001721722,0.002248426,0.000349737,0.0006059185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002009779,0.00006378638,0.000178993,0.0002493316,0.000646892,0.0001489596,0.00001007324,0.00004487961,0.981528,0.00005415813,0.01686136,0.00001262156],"study_design_scores_gemma":[0.00043937,0.0001557558,0.001317046,0.0002464846,0.0001324959,4.044736e-8,0.000001879364,0.0001015959,0.834748,0.000003068562,0.1619853,0.0008689167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908421,0.003622649,0.000650094,0.001336747,0.001320597,0.001045913,0.0008511872,0.0002517501,0.00007897113],"genre_scores_gemma":[0.9897952,0.001236565,0.003599924,0.001330958,0.002668866,0.0005054908,0.000006566098,0.0003862068,0.0004701992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1467799,"threshold_uncertainty_score":0.9994053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009893959490333072,"score_gpt":0.2556976984496993,"score_spread":0.2458037389593662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}