{"id":"W4394852260","doi":"10.1101/2024.04.12.589110","title":"Acute myeloid leukemia mitochondria hydrolyze ATP to resist chemotherapy","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Mitochondrion; Bioenergetics; Cancer research; Cancer cell; Cell biology; Oxidative phosphorylation; Myeloid leukemia; Biology; Chemistry; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301474,0.0002576829,0.0001902542,0.000129502,0.000145472,0.0003917399,0.0001537725,0.0002981847,0.00123067],"category_scores_gemma":[0.000131911,0.00009254531,0.0001173807,0.000137982,0.0001896796,0.0002878977,0.0002256729,0.0004575856,0.0004167072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900414,"about_ca_system_score_gemma":0.0001527021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003049184,"about_ca_topic_score_gemma":0.0003598399,"domain_scores_codex":[0.9999022,0.00001383605,0.000009355549,0.00002266481,0.00003082735,0.00002104188],"domain_scores_gemma":[0.9999284,0.000007835344,0.00002880145,0.00001012077,0.00001004521,0.0000147921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008985407,0.0000121488,0.0002503263,0.00003483634,0.000003355983,0.00003237234,0.000009019615,0.00008297648,0.9968114,0.000174542,0.00009324732,0.00240589],"study_design_scores_gemma":[0.00003522543,0.0004461459,0.004965372,0.00001071663,0.00001354673,0.0006384925,0.00003676559,0.001451829,0.9838759,0.0002482486,0.008272124,0.000005566641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848875,0.003481363,0.007493032,0.0005941964,0.00007322565,0.0000853845,0.0003673513,0.0002966106,0.002721443],"genre_scores_gemma":[0.9949293,0.0008192767,0.002051348,0.0001043185,0.00001129216,0.00002388509,0.0002532087,0.000009211296,0.001798207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00123067,"threshold_uncertainty_score":0.004116952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009893959490333072,"score_gpt":0.2556976984496993,"score_spread":0.2458037389593662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}