{"id":"W4394853357","doi":"10.5858/arpa.2023-0536-cp","title":"Programmed Death Ligand-1 and Tumor Mutation Burden Testing of Patients With Lung Cancer for Selection of Immune Checkpoint Inhibitor Therapies: Guideline From the College of American Pathologists, Association for Molecular Pathology, International Association for the Study of Lung Cancer, Pulmonary Pathology Society, and LUNGevity Foundation","year":2024,"lang":"en","type":"article","venue":"Archives of Pathology & Laboratory Medicine","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Association for Molecular Pathology; LUNGevity Foundation","keywords":"Medicine; Guideline; Lung cancer; Companion diagnostic; Intensive care medicine; Cancer; Grading (engineering); Immunotherapy; Clinical trial; Oncology; Biomarker; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02695602,0.001955264,0.0038883,0.006662336,0.001566165,0.003114912,0.007549696,0.009137032,0.003829956],"category_scores_gemma":[0.07519202,0.001540406,0.01068092,0.004189481,0.001341306,0.003189381,0.002774217,0.008270503,0.002795674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006855829,"about_ca_system_score_gemma":0.02253884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02491388,"about_ca_topic_score_gemma":0.0406722,"domain_scores_codex":[0.970809,0.01051715,0.01034134,0.001239727,0.006301956,0.000790865],"domain_scores_gemma":[0.9450513,0.01830785,0.008902539,0.0009785767,0.025002,0.001757639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004432068,0.0002052226,0.003331835,0.09243709,0.002912116,0.0006456843,0.0009782646,0.002569726,0.001744731,0.007339312,0.5856485,0.3017444],"study_design_scores_gemma":[0.00213017,0.0003786242,0.01029937,0.3184013,0.009625537,0.001262342,0.0005225601,0.002791891,0.001330663,0.01500527,0.6379238,0.0003284826],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.005921664,0.464591,0.04569799,0.3571486,0.01497461,0.03138477,0.02601521,0.001149488,0.05311671],"genre_scores_gemma":[0.05304551,0.3967136,0.2997195,0.1583041,0.005630435,0.03767835,0.02874841,0.0003158824,0.01984433],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.02695602,"threshold_uncertainty_score":0.1425588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076970946136144,"score_gpt":0.3078021886910949,"score_spread":0.2970324792297335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}