{"id":"W4394853712","doi":"10.1172/jci170809","title":"The estrogen signaling pathway reprograms prostate cancer cell metabolism and supports proliferation and disease progression","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research","keywords":"Prostate cancer; Estrogen receptor; Cancer research; Biology; Estrogen receptor beta; Cell growth; Androgen receptor; Estrogen; Estrogen receptor alpha; Nuclear receptor; Cancer; Endocrinology; Breast cancer; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794751,0.000176101,0.0002662085,0.0003372761,0.0001495367,0.0004834109,0.0001183128,0.0001760065,0.001683059],"category_scores_gemma":[0.000146199,0.0001181434,0.0002457506,0.0002894469,0.0001521959,0.0001589336,0.0002227901,0.0004143364,0.0003957302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571199,"about_ca_system_score_gemma":0.000435928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007637799,"about_ca_topic_score_gemma":0.001528469,"domain_scores_codex":[0.9998465,0.00003836538,0.000007505601,0.00003182107,0.00004746075,0.00002839243],"domain_scores_gemma":[0.9999433,0.00000879957,0.00001172944,0.000007065018,0.00001477701,0.00001444324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002692646,0.00004706542,0.001530949,0.0001608162,0.0000227126,0.00008919547,0.00003306265,0.0003845154,0.9817383,0.0004001785,0.000442967,0.01488101],"study_design_scores_gemma":[0.00003984827,0.000691549,0.04056111,0.00004466874,0.0000902187,0.0008082388,0.0001731794,0.002687579,0.9129403,0.0006330495,0.04129924,0.00003105035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9565263,0.02427819,0.008715726,0.0008349504,0.0001763783,0.00005813876,0.00274633,0.0004079318,0.00625593],"genre_scores_gemma":[0.9872963,0.006668582,0.001739821,0.0001763265,0.00002604285,0.00001814519,0.001056168,0.0000247843,0.002993773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001683059,"threshold_uncertainty_score":0.005630374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06051771547079411,"score_gpt":0.4157072906028091,"score_spread":0.355189575132015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}