{"id":"W4394854158","doi":"10.1101/2024.04.12.589228","title":"The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision BioLogic (Canada); University of Manitoba; Children's Hospital Research Institute of Manitoba; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta","keywords":"Thioredoxin; Cell biology; Mitochondrion; Peroxiredoxin; Endoplasmic reticulum; Voltage-dependent anion channel; Cytosol; Intermembrane space; Transmembrane protein; Inner mitochondrial membrane; Oxidative phosphorylation; Chemistry; Biology; Biochemistry; Oxidative stress; Bacterial outer membrane; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001051012,0.0005565308,0.0003224417,0.0002763378,0.0002107665,0.000304996,0.0002844832,0.000335204,0.007287601],"category_scores_gemma":[0.00009641497,0.0001449492,0.0003264429,0.0002292034,0.0001544754,0.0003728703,0.0002762793,0.0006326998,0.0009796517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473267,"about_ca_system_score_gemma":0.0001532301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004107377,"about_ca_topic_score_gemma":0.0004476667,"domain_scores_codex":[0.9999146,0.000008723883,0.00000420586,0.0000243464,0.00002582694,0.00002227101],"domain_scores_gemma":[0.9999431,0.000005414788,0.00002424944,0.000003756352,0.000009774665,0.00001373228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004000761,0.00003547124,0.0004012128,0.0005994792,0.00003428025,0.0002206364,0.00003936942,0.001022885,0.9844849,0.001847551,0.002818007,0.008096077],"study_design_scores_gemma":[0.00005398568,0.0001941757,0.004151539,0.00004443253,0.00005296094,0.0002954271,0.00006279133,0.007451847,0.9670046,0.0008665064,0.0198011,0.00002069079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9171365,0.01893256,0.03488047,0.00321776,0.001233371,0.0001332975,0.006952851,0.001660617,0.01585274],"genre_scores_gemma":[0.9788134,0.004986285,0.004592211,0.0001963453,0.00008510437,0.00004616818,0.001779682,0.00006042567,0.009440403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007287601,"threshold_uncertainty_score":0.02437943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006612620832925778,"score_gpt":0.2177260124939404,"score_spread":0.2111133916610146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}