{"id":"W4394858592","doi":"10.1016/j.jad.2024.04.039","title":"Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis","year":2024,"lang":"en","type":"review","venue":"Journal of Affective Disorders","topic":"Treatment of Major Depression","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Ottawa; Brain and Cognition Discovery Foundation","funders":"","keywords":"Ketamine; Number needed to treat; Treatment-resistant depression; Medicine; Number needed to harm; Placebo; Meta-analysis; Randomized controlled trial; MEDLINE; Publication bias; Major depressive disorder; Anesthesia; Psychiatry; Relative risk; Internal medicine; Confidence interval; Alternative medicine; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000520899,0.0009156668,0.01125343,0.001020021,0.00005239529,0.00005484889,0.0001170821,0.0001951778,0.00003938423],"category_scores_gemma":[0.000389516,0.0004077655,0.002342554,0.001259961,0.00005866078,0.0001329338,0.00005201692,0.000288736,0.000004489574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003868922,"about_ca_system_score_gemma":0.0001619048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001261603,"about_ca_topic_score_gemma":0.0005764687,"domain_scores_codex":[0.9968288,0.0004290022,0.00132744,0.0006643794,0.0004469464,0.0003034385],"domain_scores_gemma":[0.9970446,0.0009069556,0.00105505,0.0004647581,0.000202441,0.0003261716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0006330522,0.000532097,0.00008277894,0.8135024,0.1612011,0.0002336751,0.0002345079,0.000001024724,5.615324e-7,0.000002893327,0.0003241698,0.02325181],"study_design_scores_gemma":[0.002971674,0.002247731,0.00004763132,0.1826032,0.8085845,0.0004802272,0.0001734938,0.00000313141,0.00000163656,0.000006971138,0.0025869,0.0002928843],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004481538,0.9897205,0.00005767484,0.0005534857,0.00002459943,0.008963745,0.0001206131,0.00001681582,0.0000943674],"genre_scores_gemma":[0.0009058263,0.9958104,0.0005461987,0.0001097571,0.00002904128,0.00151059,0.00005206376,0.0001000924,0.0009360198],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6473834,"threshold_uncertainty_score":0.9998374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850738130220729,"score_gpt":0.3566490709189915,"score_spread":0.3281416896167841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}