{"id":"W4394879176","doi":"10.3390/ph17040513","title":"Human ABC and SLC Transporters: The Culprit Responsible for Unspecific PSMA-617 Uptake?","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsches Krebsforschungszentrum; Bayer","keywords":"ATP-binding cassette transporter; Abcg2; Transporter; Efflux; Multiple drug resistance; Organic anion transporter 1; Pharmacology; Multidrug resistance-associated protein 2; Prodrug; Solute carrier family; Multidrug Resistance-Associated Proteins; Chemistry; Organic anion-transporting polypeptide; Drug resistance; Biology; Biochemistry; Gene; Microbiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007190218,0.000215148,0.0003105621,0.0001082794,0.0002418612,0.00007500475,0.0001251219,0.00009495158,0.0005587602],"category_scores_gemma":[0.00001235163,0.0001363372,0.0002051976,0.0002274613,0.0002048314,0.00008505395,0.000009024915,0.0003187805,0.00006548415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003115998,"about_ca_system_score_gemma":0.00008896017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002359891,"about_ca_topic_score_gemma":0.000009067123,"domain_scores_codex":[0.9985328,0.00002997213,0.0003622032,0.0004221161,0.0002394006,0.0004134657],"domain_scores_gemma":[0.9992722,0.0001409846,0.00002386153,0.0002732353,0.00005326051,0.0002365021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002159826,0.0004947991,0.0007815253,0.003717344,0.0009585174,0.0007822749,0.003978886,0.000005335613,0.6214452,0.2718172,0.01611528,0.07774378],"study_design_scores_gemma":[0.001958532,0.0001633025,0.002680587,0.0003758502,0.0008727401,0.00005979788,0.0003438876,0.0005808276,0.05751269,0.007297939,0.9278942,0.0002596275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7405519,0.07245007,0.02167398,0.1189322,0.003625095,0.007637202,0.0004471506,0.001675474,0.03300689],"genre_scores_gemma":[0.9850017,0.0007554065,0.001015856,0.001309916,0.0004466978,0.0001284993,0.00003923732,0.00006190964,0.01124072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9117789,"threshold_uncertainty_score":0.6118032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07726592751891108,"score_gpt":0.402479020309816,"score_spread":0.3252130927909049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}