{"id":"W4394879176","doi":"10.3390/ph17040513","title":"Human ABC and SLC Transporters: The Culprit Responsible for Unspecific PSMA-617 Uptake?","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsches Krebsforschungszentrum; Bayer","keywords":"ATP-binding cassette transporter; Abcg2; Transporter; Efflux; Multiple drug resistance; Organic anion transporter 1; Pharmacology; Multidrug resistance-associated protein 2; Prodrug; Solute carrier family; Multidrug Resistance-Associated Proteins; Chemistry; Organic anion-transporting polypeptide; Drug resistance; Biology; Biochemistry; Gene; Microbiology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004373909,0.0002918777,0.0007660339,0.0003101433,0.0001787784,0.0008717734,0.0001985356,0.0008311931,0.003430624],"category_scores_gemma":[0.0005246528,0.0002150827,0.0002892477,0.0003888174,0.00045057,0.0007406973,0.0001918077,0.0004276575,0.002141447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005686935,"about_ca_system_score_gemma":0.0002838779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008022632,"about_ca_topic_score_gemma":0.0006533842,"domain_scores_codex":[0.9996606,0.00007304443,0.00002523358,0.00008437612,0.00008525006,0.0000715505],"domain_scores_gemma":[0.9997959,0.00004375037,0.00005086213,0.00002420456,0.00006488946,0.00002043026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007934954,0.00007385403,0.0172195,0.001090971,0.000135809,0.004092257,0.0004160958,0.0003631217,0.8953239,0.006771868,0.004453841,0.06926531],"study_design_scores_gemma":[0.00006174328,0.0004463839,0.03360754,0.00009910995,0.0002398814,0.01980208,0.0006244772,0.004337096,0.854612,0.003575882,0.08255104,0.00004271655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8405258,0.09583487,0.03710999,0.008166303,0.0003808128,0.0001587111,0.00105659,0.0007245839,0.0160423],"genre_scores_gemma":[0.9685818,0.01512307,0.004585607,0.001130187,0.000221652,0.00005017498,0.0007536558,0.00008842313,0.00946538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003430624,"threshold_uncertainty_score":0.01147664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07726592751891108,"score_gpt":0.402479020309816,"score_spread":0.3252130927909049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}