{"id":"W4394891173","doi":"10.1099/acmi.0.000675.v2","title":"Deciphering the interaction surface between the West Nile virus NS3 and NS5 proteins","year":2024,"lang":"en","type":"preprint","venue":"","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"NS3; Flavivirus; Virology; Dengue virus; Zika virus; Dengue fever; Flaviviridae; Japanese encephalitis; Biology; In silico; Replicon; Viral replication; Virus; West Nile virus; Encephalitis; Hepatitis C virus; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009143373,0.0004042729,0.000295055,0.0001908292,0.0002426212,0.0002926312,0.0002453978,0.0003382994,0.001679105],"category_scores_gemma":[0.0001817261,0.0001317841,0.0004280589,0.0001173072,0.0001291848,0.0004735024,0.0002360201,0.0003169683,0.0003588543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133287,"about_ca_system_score_gemma":0.0001801984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002301991,"about_ca_topic_score_gemma":0.001802177,"domain_scores_codex":[0.9999564,0.000008105938,0.000001823088,0.000009393068,0.00001315817,0.00001118817],"domain_scores_gemma":[0.9999715,0.0000135581,0.000004940626,0.000001968319,0.000003688682,0.000004437961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005766,0.0001614293,0.01224238,0.000325524,0.0001378584,0.0007061236,0.0001725613,0.06440777,0.9063804,0.003050994,0.0006688244,0.01116955],"study_design_scores_gemma":[0.0000295566,0.0002237663,0.01254336,0.00002191407,0.00009273353,0.0002399995,0.0002511952,0.75253,0.2294366,0.002214945,0.002388316,0.0000275944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870071,0.001008607,0.009926828,0.0001233289,0.00001457458,0.000009366934,0.000229349,0.00007602989,0.001604797],"genre_scores_gemma":[0.9947903,0.000600595,0.00371136,0.00002163066,0.000002741938,0.000006118454,0.0004110432,0.0000138046,0.0004423984],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002301991,"threshold_uncertainty_score":0.005617142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299935054578115,"score_gpt":0.3041522217251068,"score_spread":0.2811528711793256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}