{"id":"W4394922589","doi":"10.20944/preprints202404.1036.v1","title":"Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2, Against MASLD Progression","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Hepatocyte; NRF1; Chemistry; Oxidative stress; Pharmacology; Medicine; Biochemistry; Transcription factor; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205664,0.0004193758,0.0003342796,0.0001922834,0.0001240924,0.0001556019,0.0001426826,0.0002384121,0.001522148],"category_scores_gemma":[0.0001085522,0.00009568562,0.000194414,0.00007668454,0.0002045079,0.0002994838,0.0001912806,0.0003565268,0.0001876673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001296082,"about_ca_system_score_gemma":0.0002007793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00015733,"about_ca_topic_score_gemma":0.0004511747,"domain_scores_codex":[0.9999142,0.00001748782,0.000008882718,0.00001980359,0.00001618465,0.0000234306],"domain_scores_gemma":[0.9998873,0.00000902716,0.0000359108,0.00001053021,0.00001728099,0.00003989452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001437384,0.000127064,0.000717287,0.0001177712,0.00001855891,0.00004855008,0.00001978619,0.00005884446,0.9941996,0.00006784404,0.00006021481,0.003126991],"study_design_scores_gemma":[0.0001426992,0.005184344,0.01294005,0.00002580859,0.00008024,0.0004558745,0.00007037965,0.0005181798,0.9773841,0.00009821707,0.003089802,0.00001023851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953759,0.002484708,0.001134637,0.0001258227,0.00002686452,0.00002551446,0.0001633321,0.00005852215,0.0006047259],"genre_scores_gemma":[0.9957358,0.001027514,0.001482956,0.00005326252,0.00001421425,0.00004450751,0.0002484637,0.000008088601,0.00138524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522148,"threshold_uncertainty_score":0.005092084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05895997030529987,"score_gpt":0.349956419013958,"score_spread":0.2909964487086581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}