{"id":"W4394923835","doi":"10.1038/s41467-024-47623-8","title":"Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Simon Fraser University","funders":"Common Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Office of Research Infrastructure Programs, National Institutes of Health; Parkinson Canada; Canadian Institutes of Health Research; NIH Office of the Director; Intellectual and Developmental Disabilities Research Center; National Institutes of Health; Government of Canada","keywords":"Mitochondrial fission; PINK1; Phosphorylation; Cell biology; Drosophila (subgenus); Biology; Phenotype; Mitochondrial DNA; Mitochondrion; Genetics; Mitophagy; Apoptosis; Gene; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008927218,0.000400534,0.000175117,0.0003213697,0.0001878701,0.0002119104,0.000240647,0.0001368611,0.002128382],"category_scores_gemma":[0.0001119631,0.0001275622,0.0001640025,0.0001190461,0.0002058696,0.0001641631,0.0002521297,0.0002922213,0.0006081925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004278162,"about_ca_system_score_gemma":0.0001950925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001014657,"about_ca_topic_score_gemma":0.001896233,"domain_scores_codex":[0.9999282,0.00001005552,0.000009167488,0.00001837108,0.00001751009,0.00001660432],"domain_scores_gemma":[0.9998994,0.00001279851,0.00003022605,0.00001171022,0.000008209308,0.00003761707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008214486,0.00001214747,0.0002501642,0.00003503995,0.000003882089,0.00009940666,0.000005769229,0.0001196586,0.998165,0.000199745,0.00006403472,0.000963019],"study_design_scores_gemma":[0.0000194317,0.00004685279,0.002962209,0.000004441621,0.000006861508,0.0001968116,0.000009613611,0.0008575018,0.9927768,0.00006726141,0.003049798,0.000002480579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891652,0.00157227,0.003516676,0.0001795377,0.00003367583,0.00003155735,0.00119096,0.0002065145,0.004103548],"genre_scores_gemma":[0.9932174,0.0006793333,0.002211932,0.00003062341,0.000006289292,0.00002484685,0.0004884177,0.00004733702,0.003293849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128382,"threshold_uncertainty_score":0.007120192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466261912287886,"score_gpt":0.288548335110809,"score_spread":0.2738857159879301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}