{"id":"W4394927992","doi":"10.1016/j.joca.2024.02.431","title":"PHARMACOKINETICS OF EP-104IAR LONG-ACTING FLUTICASONE PROPIONATE FOR INTRA ARTICULAR INJECTION IN 163 SUBJECTS FROM SPRINGBOARD, A PHASE 2 STUDY IN KNEE OSTEOARTHRITIS","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Osteoarthritis; Fluticasone propionate; Pharmacokinetics; Intra articular; Medicine; Phase (matter); Propionate; Pharmacology; Internal medicine; Chemistry; Corticosteroid; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153043,0.001256702,0.001703595,0.0003859335,0.0006296835,0.0008881158,0.0004524131,0.001234509,0.00221541],"category_scores_gemma":[0.001151834,0.001004396,0.001084958,0.0003255053,0.0007181424,0.0007548353,0.0002108061,0.001779714,0.0009117099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006081547,"about_ca_system_score_gemma":0.0009995678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004638584,"about_ca_topic_score_gemma":0.005024558,"domain_scores_codex":[0.9994808,0.0001982226,0.00002347812,0.0001253954,0.00006572643,0.0001063617],"domain_scores_gemma":[0.9994889,0.0001137558,0.00008554536,0.00004927204,0.00005493522,0.0002074941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6794109,0.02790437,0.02768334,0.0003573521,0.001184906,0.0007602908,0.001285657,0.001227198,0.1952229,0.00008222832,0.001626231,0.06325465],"study_design_scores_gemma":[0.1196382,0.5892566,0.2667565,0.00004195609,0.001709876,0.0006849528,0.0006649112,0.00243493,0.01651857,0.00009762789,0.002022616,0.0001731662],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983392,0.0004872307,0.0002960235,0.00004858778,0.00002936679,0.0002025304,0.0002191585,0.00004218337,0.0003357326],"genre_scores_gemma":[0.996617,0.000365403,0.0003876071,0.0001785935,0.00007227869,0.0001776407,0.0004922518,0.00002796338,0.001681377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004638584,"threshold_uncertainty_score":0.009223163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721917263450755,"score_gpt":0.3432168767433915,"score_spread":0.3159977041088839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}