{"id":"W4394927992","doi":"10.1016/j.joca.2024.02.431","title":"PHARMACOKINETICS OF EP-104IAR LONG-ACTING FLUTICASONE PROPIONATE FOR INTRA ARTICULAR INJECTION IN 163 SUBJECTS FROM SPRINGBOARD, A PHASE 2 STUDY IN KNEE OSTEOARTHRITIS","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Osteoarthritis; Fluticasone propionate; Pharmacokinetics; Intra articular; Medicine; Phase (matter); Propionate; Pharmacology; Internal medicine; Chemistry; Corticosteroid; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007448065,0.0003493171,0.0006522824,0.0002228167,0.00006980562,0.00013528,0.0001427942,0.0001964458,0.0003039188],"category_scores_gemma":[0.0004016088,0.0003764631,0.0001476998,0.0004761141,0.0001852353,0.0002358551,0.0001415631,0.0005606549,0.000007793989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001033135,"about_ca_system_score_gemma":0.00006267457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000051056,"about_ca_topic_score_gemma":0.000329619,"domain_scores_codex":[0.9971778,0.0001777959,0.0009404861,0.0007787603,0.0003342777,0.0005908957],"domain_scores_gemma":[0.9986143,0.000678957,0.000108637,0.0003120622,0.0000835442,0.0002025614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006138326,0.0007407131,0.007029101,0.0006107173,0.00003552048,0.0008839361,0.001566166,0.00003986438,0.5707759,0.0002188726,0.00001114194,0.4174742],"study_design_scores_gemma":[0.0199263,0.002240364,0.0003247208,0.002090584,0.000410191,0.00008029937,0.002973876,0.007772906,0.9591483,0.001534539,0.00263523,0.0008626428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892912,0.007457046,0.001035272,0.00007995848,0.0003135713,0.0009076945,0.000162597,0.00009406887,0.0006585902],"genre_scores_gemma":[0.9974678,0.0001562006,0.001604318,0.00004732639,0.0002142479,0.0003154247,0.00002564961,0.00007005938,0.00009894653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4166116,"threshold_uncertainty_score":0.9998688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721917263450755,"score_gpt":0.3432168767433915,"score_spread":0.3159977041088839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}