{"id":"W4394934096","doi":"10.1021/acssensors.4c00090","title":"CRISPR/Cas14 and G-Quadruplex DNAzyme-Driven Biosensor for Paper-Based Colorimetric Detection of African Swine Fever Virus","year":2024,"lang":"en","type":"article","venue":"ACS Sensors","topic":"Animal Disease Management and Epidemiology","field":"Agricultural and Biological Sciences","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health; Virginia Polytechnic Institute and State University","keywords":"Deoxyribozyme; Detection limit; CRISPR; African swine fever virus; Virology; Biosensor; Biology; DNA; Virus; Chemistry; Chromatography; Gene; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005778477,0.0006946741,0.0004007786,0.0004496512,0.0001771827,0.0005527952,0.0009968688,0.001249393,0.0006590947],"category_scores_gemma":[0.0007474665,0.0004118055,0.0005156624,0.000278259,0.000319484,0.000511046,0.0005705478,0.0006865609,0.0003687745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004855935,"about_ca_system_score_gemma":0.0003464995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004640962,"about_ca_topic_score_gemma":0.0008045799,"domain_scores_codex":[0.9991078,0.000151534,0.00006793286,0.0002577793,0.00033978,0.00007519152],"domain_scores_gemma":[0.9996469,0.0001056954,0.0001115668,0.00002769187,0.00007238423,0.00003580229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003112269,0.0000214849,0.0001518917,0.00005392822,0.0000099522,0.00004366179,0.00001229253,0.0001836865,0.9963138,0.00008257343,0.00005872759,0.003036958],"study_design_scores_gemma":[0.000007025974,0.0001274941,0.0005335369,0.000003628916,0.00001218224,0.0001468822,0.00001169454,0.003308617,0.99477,0.00003715503,0.00102881,0.00001305571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7950607,0.004552792,0.194001,0.0005177405,0.0004271237,0.0003120347,0.0006249087,0.001290649,0.003213104],"genre_scores_gemma":[0.8390052,0.001622219,0.1530219,0.000298506,0.0000526821,0.0002585828,0.000373135,0.00003473779,0.005332992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249393,"threshold_uncertainty_score":0.00352329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03083581732954915,"score_gpt":0.256667806388956,"score_spread":0.2258319890594068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}