{"id":"W4394934846","doi":"10.1016/j.joca.2024.02.074","title":"EFFICACY OUTCOMES IN PATIENTS WITH KNEE OSTEOARTHRITIS: PER-PROTOCOL ANALYSES FROM SPRINGBOARD, A PHASE 2, RANDOMIZED, 24-WEEK STUDY OF EP-104IAR (LONG-ACTING INTRA-ARTICULAR INJECTION OF FLUTICASONE PROPIONATE)","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Osteoarthritis; Fluticasone propionate; Protocol (science); Physical therapy; Randomized controlled trial; Intra articular; Surgery; Corticosteroid; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01141562,0.003086763,0.005452672,0.001098715,0.0006985132,0.001335648,0.001169186,0.002369703,0.005840163],"category_scores_gemma":[0.007629491,0.001126906,0.006574998,0.0008884155,0.001488451,0.002024286,0.0009207964,0.003547479,0.0007450972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129321,"about_ca_system_score_gemma":0.002058994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008909866,"about_ca_topic_score_gemma":0.002615231,"domain_scores_codex":[0.9933427,0.004681055,0.0004535239,0.0005410729,0.0004031835,0.0005784683],"domain_scores_gemma":[0.9944996,0.001955247,0.001782833,0.0005881617,0.0003855962,0.0007885123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9833983,0.003792357,0.0008298423,0.0003895661,0.002920116,0.00001998693,0.00003445362,0.0002530031,0.001198182,0.00002404819,0.0002708969,0.006869286],"study_design_scores_gemma":[0.8995116,0.08962735,0.00740262,0.00003152043,0.002459776,0.00002285233,0.00003026368,0.0002667018,0.0003209447,0.00006610921,0.000237744,0.00002251542],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828114,0.004015426,0.001529024,0.0003476699,0.0002392354,0.006586196,0.002548534,0.0001891804,0.001733389],"genre_scores_gemma":[0.9819103,0.001435261,0.00310134,0.0007039209,0.0003348933,0.008332429,0.002336644,0.0000543296,0.001790782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01141562,"threshold_uncertainty_score":0.06037229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358611990084717,"score_gpt":0.2936730446799355,"score_spread":0.2800869247790884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}