{"id":"W4394935596","doi":"10.1016/j.bpj.2024.03.027","title":"Kinetic cooperativity resolves bidirectional clogging within the nuclear pore complex","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Compute Canada","keywords":"Clogging; Cooperativity; Kinetic energy; Nuclear pore; Biophysics; Chemistry; Chemical physics; Physics; Biology; Classical mechanics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00120661,0.0004537868,0.001019984,0.0005850568,0.001340711,0.002929898,0.001636372,0.001087143,0.004340589],"category_scores_gemma":[0.005122329,0.0008831031,0.000322697,0.0003223431,0.001845111,0.002867693,0.002021274,0.001790839,0.0008907957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001091962,"about_ca_system_score_gemma":0.0008638787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007302574,"about_ca_topic_score_gemma":0.0009366544,"domain_scores_codex":[0.9990869,0.0001244884,0.00005315185,0.0002314389,0.0002335971,0.0002705056],"domain_scores_gemma":[0.9956156,0.001995215,0.0005803257,0.0008392226,0.0003680508,0.0006015789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001617665,0.0004908032,0.003937763,0.0003600617,0.00005363218,0.0008273427,0.0007599983,0.01180895,0.9143438,0.05363232,0.001155621,0.01101205],"study_design_scores_gemma":[0.0002819202,0.0004203265,0.004906496,0.00006020882,0.00006978912,0.0008744711,0.001044747,0.2064105,0.7366691,0.04491394,0.004103392,0.000245221],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769571,0.0002899545,0.01761566,0.0004745433,0.00009512164,0.00004096136,0.00006298762,0.0003762805,0.004087307],"genre_scores_gemma":[0.9983881,0.00005163219,0.0009690851,0.0000349846,0.000008334554,0.00001244412,0.00003045172,0.00005305929,0.0004519956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004340589,"threshold_uncertainty_score":0.0145207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328107046761121,"score_gpt":0.2478593405531146,"score_spread":0.2345782700855034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}