{"id":"W4394940887","doi":"10.2196/54042","title":"A Predictive Noninvasive Single-Nucleotide Variation–Based Biomarker Signature for Resectable Pancreatic Cancer: Protocol for a Prospective Validation Study","year":2024,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Pancreatic cancer; Oncology; Internal medicine; Prospective cohort study; Genotyping; Biomarker; Cohort; Bioinformatics; Cancer; Genotype; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03702934,0.003012458,0.00330395,0.002073872,0.003283963,0.002020364,0.002812715,0.003144865,0.03532509],"category_scores_gemma":[0.03014694,0.001820128,0.003384711,0.002355753,0.001937573,0.001692583,0.002679037,0.003730088,0.01482609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00281293,"about_ca_system_score_gemma":0.01420903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001873025,"about_ca_topic_score_gemma":0.002311952,"domain_scores_codex":[0.9840249,0.008246091,0.003143027,0.001736602,0.001843494,0.00100587],"domain_scores_gemma":[0.9733503,0.003895426,0.003415712,0.006347497,0.0110171,0.001974053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2859024,0.0301927,0.0682713,0.03607999,0.00348582,0.00300977,0.002807153,0.01683481,0.0388909,0.0161023,0.1873035,0.3111194],"study_design_scores_gemma":[0.1621967,0.06917183,0.1814214,0.01632463,0.002890171,0.002159341,0.001446045,0.01024222,0.01826951,0.01384824,0.5209556,0.001074242],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006953717,0.0004418618,0.01136888,0.0002527178,0.0003159737,0.9713275,0.006669631,0.0001794573,0.002490253],"genre_scores_gemma":[0.00294197,0.0001158342,0.005264801,0.0001359673,0.00003817815,0.989562,0.001583282,0.00001367908,0.000344296],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.03702934,"threshold_uncertainty_score":0.1958322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2442478084465124,"score_gpt":0.5537216349590434,"score_spread":0.309473826512531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}