{"id":"W4394951960","doi":"10.2337/dbi23-0031","title":"Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?","year":2024,"lang":"en","type":"review","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Adenosine triphosphate; Glycolysis; Mitochondrion; Cytosol; Bioenergetics; ATP synthase; Cell biology; Membrane potential; ATP–ADP translocase; Biology; Depolarization; Adenosine diphosphate; Biochemistry; Cellular respiration; Biophysics; Inner mitochondrial membrane; Phosphoenolpyruvate carboxykinase; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000180313,0.0004634746,0.002034098,0.0004520599,0.00002733903,0.00003503444,0.0001269637,0.000398016,0.0003799518],"category_scores_gemma":[0.000115587,0.0003437582,0.0007813073,0.0005570307,0.00005271739,0.00006712103,0.0000674792,0.0003068629,0.000563836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008744592,"about_ca_system_score_gemma":0.0005976502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001500633,"about_ca_topic_score_gemma":7.792266e-8,"domain_scores_codex":[0.9981236,0.00004142876,0.0007047978,0.000459021,0.0003358512,0.0003353008],"domain_scores_gemma":[0.9986861,0.0001451135,0.000282915,0.0005509937,0.00009026896,0.0002445492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001286112,0.0002167006,0.00001158026,0.1168973,0.0008050317,0.000003822353,0.0003950812,0.00001282707,0.001226943,0.0003248631,0.1581591,0.7219339],"study_design_scores_gemma":[0.0005933021,0.0001883387,8.917466e-7,0.03013646,0.007393661,0.000002586637,0.00003368223,0.009116226,0.006808651,0.0009455262,0.9443576,0.0004230529],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001198097,0.9898235,0.00003229966,0.0001120867,0.0004902843,0.0006914744,0.00007733629,0.0001434394,0.00743144],"genre_scores_gemma":[0.0002081755,0.968276,0.0006768905,0.0003789684,0.0004941957,0.00006851606,0.0003267594,0.0001061139,0.02946439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7861985,"threshold_uncertainty_score":0.9999014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05244836638942347,"score_gpt":0.3068408487667965,"score_spread":0.254392482377373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}