{"id":"W4394952465","doi":"10.7554/elife.86354","title":"MEMO1 binds iron and modulates iron homeostasis in cancer cells","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Oregon Health and Science University; Saskatchewan Cancer Agency; University of Saskatchewan; Canadian Light Source; Canada Foundation for Innovation; University of Wisconsin-Madison","keywords":"Cancer cell; Motility; Transferrin receptor; Regulator; Biology; Cell biology; Ferritin; Transferrin; Ferroportin; Intracellular; Mediator; Function (biology); Biochemistry; Mitochondrion; Gene; Cancer; Genetics; Iron homeostasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007040604,0.0002001966,0.0001369358,0.0001216468,0.0002122661,0.0001973607,0.0001688086,0.0002273308,0.001075196],"category_scores_gemma":[0.00009480274,0.00009448667,0.00009694081,0.0001077989,0.0001284549,0.0001071293,0.0002290662,0.0002780304,0.0004085878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494049,"about_ca_system_score_gemma":0.00009577956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000604353,"about_ca_topic_score_gemma":0.0008984931,"domain_scores_codex":[0.9999367,0.000006265692,0.00000288859,0.00001386765,0.00001831545,0.00002194735],"domain_scores_gemma":[0.9999654,0.000004067183,0.00001016322,0.000003571092,0.000004922264,0.00001191612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008739852,0.000007678535,0.0004918538,0.00002819897,0.00000217964,0.00006156496,0.00001354432,0.00003968235,0.9975536,0.00008313468,0.0001653785,0.001465759],"study_design_scores_gemma":[0.00002102234,0.00007880909,0.02086649,0.00001034319,0.000009303411,0.0002462485,0.00008985795,0.001395399,0.9672031,0.0001043117,0.009970616,0.000004510439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916923,0.001898356,0.002088531,0.0002814977,0.00004638066,0.00001316731,0.0006119005,0.0001153237,0.003252517],"genre_scores_gemma":[0.9918278,0.0009070194,0.001289917,0.00008951149,0.000009710761,0.00002733153,0.0008206262,0.00001799907,0.005010038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075196,"threshold_uncertainty_score":0.003596902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073052239474455,"score_gpt":0.2727622428117956,"score_spread":0.2620317204170511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}