{"id":"W4394952465","doi":"10.7554/elife.86354","title":"MEMO1 binds iron and modulates iron homeostasis in cancer cells","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Oregon Health and Science University; Saskatchewan Cancer Agency; University of Saskatchewan; Canadian Light Source; Canada Foundation for Innovation; University of Wisconsin-Madison","keywords":"Cancer cell; Motility; Transferrin receptor; Regulator; Biology; Cell biology; Ferritin; Transferrin; Ferroportin; Intracellular; Mediator; Function (biology); Biochemistry; Mitochondrion; Gene; Cancer; Genetics; Iron homeostasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006606455,0.00007833404,0.00006454357,0.00004100299,0.0000255914,0.00003296245,0.00005649521,0.00007387636,0.00004307088],"category_scores_gemma":[0.000004121298,0.00007045511,0.00002461824,0.00008203272,0.00003146182,0.00000326682,0.00003454161,0.00005262332,0.00001004261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001805324,"about_ca_system_score_gemma":0.00004304609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001394756,"about_ca_topic_score_gemma":0.0001108665,"domain_scores_codex":[0.9994666,0.00001323454,0.00009400947,0.0002395452,0.00006402051,0.000122566],"domain_scores_gemma":[0.9997831,0.000003916941,0.00001301361,0.0001458689,0.00001516033,0.00003894422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001239518,0.00002221581,0.001350043,0.00005165848,0.00001376957,0.000003147041,0.0001080059,0.0004024779,0.9491149,0.00006262581,0.006699712,0.04215907],"study_design_scores_gemma":[0.0002631144,0.00007595323,0.01062277,0.00003979908,0.00001729558,0.000002782698,0.0001226233,0.001222232,0.8315023,0.00002228971,0.1558829,0.000225954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969888,0.02897992,0.00006122854,0.0003958578,0.0001786571,0.00006773302,0.00003476645,0.00001027044,0.0003835417],"genre_scores_gemma":[0.9875993,0.01069886,0.00008994,0.0001564033,0.0001625332,0.00003763138,0.00002574562,0.00001466568,0.001214973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1491832,"threshold_uncertainty_score":0.2873076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073052239474455,"score_gpt":0.2727622428117956,"score_spread":0.2620317204170511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}