{"id":"W4394961830","doi":"10.1002/ejhf.3236","title":"A Roadmap for Therapeutic Discovery in Pulmonary Hypertension Associated with Left Heart Failure. A Scientific Statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function","year":2024,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"Cilag; HORIZON EUROPE Framework Programme; Nederlandse Federatie van Universitair Medische Centra; Servier; Novo Nordisk Fonden; Genesis Pharma; Novo Nordisk; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; European Society of Cardiology; Koninklijke Nederlandse Akademie van Wetenschappen; Deutsche Forschungsgemeinschaft; European Commission; Ministerstvo Zdravotnictví Ceské Republiky; Sanofi; Abiomed; CareDx; British Heart Foundation; Amicus Therapeutics; Cytokinetics; Eli Lilly and Company; U.S. Department of Defense; Deutsches Zentrum für Herz-Kreislaufforschung; National Institutes of Health; Regeneron Pharmaceuticals; National Heart, Lung, and Blood Institute; Acceleron; United Therapeutics Corporation; Bristol-Myers Squibb; AstraZeneca; Vifor Pharma; Ministero della Salute; Pfizer; American Heart Association","keywords":"Medicine; Heart failure; Pulmonary hypertension; Clinical endpoint; Clinical trial; Clinical Practice; Cardiology; Hypertension treatment; Intensive care medicine; Internal medicine; Blood pressure; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008861529,0.001214877,0.002880658,0.002085523,0.0008080293,0.005224691,0.001416388,0.004986772,0.01839241],"category_scores_gemma":[0.008175682,0.0005149876,0.002460701,0.001250297,0.001799325,0.005834045,0.002739879,0.00822842,0.00663178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001300548,"about_ca_system_score_gemma":0.006851538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007617072,"about_ca_topic_score_gemma":0.002028357,"domain_scores_codex":[0.9979894,0.0007954187,0.0002003684,0.0002203292,0.0004586311,0.0003358091],"domain_scores_gemma":[0.9897328,0.005000378,0.0006762011,0.0004253072,0.002624505,0.001540849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001159188,0.001015152,0.001032927,0.009431052,0.0002965132,0.0007257204,0.0003360036,0.001130308,0.01067809,0.03130785,0.1877551,0.7551321],"study_design_scores_gemma":[0.0007279232,0.002845148,0.002298722,0.006658867,0.0005124535,0.0008453645,0.0003897078,0.001468693,0.001973679,0.04226089,0.9399043,0.0001142833],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003485147,0.7987227,0.01532066,0.1529825,0.01193364,0.0004822291,0.001150955,0.000750089,0.01517202],"genre_scores_gemma":[0.02877185,0.8396907,0.04040433,0.05899019,0.01918783,0.001107762,0.002600833,0.0002629613,0.008983513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01839241,"threshold_uncertainty_score":0.06152874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919416961264266,"score_gpt":0.2404647212937438,"score_spread":0.2212705516811011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}