{"id":"W4394961878","doi":"10.1002/jcph.2444","title":"Quantitative Assessment of Drug Efficacy and Emergence of Resistance in Patients with Metastatic Renal Cell Carcinoma Using a Longitudinal Exposure‐Tumor Growth Inhibition Model: Apitolisib (Dual PI3K/mTORC1/2 Inhibitor) Versus Everolimus (mTORC1 Inhibitor)","year":2024,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Everolimus; Discovery and development of mTOR inhibitors; mTORC1; Renal cell carcinoma; PI3K/AKT/mTOR pathway; Medicine; Oncology; Drug resistance; Cancer research; Drug; Sirolimus; Internal medicine; Pharmacology; Chemistry; Biology; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005801329,0.0004710861,0.0004227031,0.0002393872,0.0001218281,0.000454803,0.0004799954,0.0007003062,0.001298129],"category_scores_gemma":[0.001103909,0.000221761,0.0009141403,0.0002003463,0.000286795,0.0002699672,0.0003565103,0.0007350771,0.0002157336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007727598,"about_ca_system_score_gemma":0.0005441948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007043527,"about_ca_topic_score_gemma":0.002738784,"domain_scores_codex":[0.9998351,0.00005017695,0.00000767719,0.0000479985,0.00002626828,0.00003286802],"domain_scores_gemma":[0.9994336,0.0003271901,0.0001277761,0.00003079377,0.00005189464,0.00002877528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001394033,0.0005973075,0.0255218,0.0001935919,0.0001639842,0.0002696704,0.0001190409,0.9238488,0.03510796,0.001446187,0.0005557635,0.01078192],"study_design_scores_gemma":[0.0000392035,0.0008389744,0.006034287,0.000007791147,0.00006801015,0.0001285962,0.00002668889,0.9828494,0.009098326,0.0004477622,0.0004402065,0.00002062275],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9588898,0.0005189124,0.0367437,0.0002640227,0.00002043347,0.00008991636,0.001228195,0.0002366097,0.002008261],"genre_scores_gemma":[0.9963248,0.0001305478,0.002157046,0.00003751649,0.000002673618,0.00006967623,0.0003362439,0.00001116648,0.0009302571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007043527,"threshold_uncertainty_score":0.01400506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07965369007208031,"score_gpt":0.4042599864395211,"score_spread":0.3246062963674408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}