{"id":"W4394963525","doi":"10.7554/elife.88225.3.sa0","title":"eLife assessment: The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Transmembrane protein; Transmembrane domain; Biology; Cell biology; Genetics; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005548391,0.0006416738,0.0007284578,0.002823762,0.001929719,0.004218674,0.001275536,0.001508226,0.1432137],"category_scores_gemma":[0.01701388,0.0004424196,0.0004975575,0.00142487,0.001011824,0.001854542,0.003321615,0.001516365,0.06283654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001871039,"about_ca_system_score_gemma":0.006684956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002502367,"about_ca_topic_score_gemma":0.009484965,"domain_scores_codex":[0.9943529,0.0004775834,0.0003712545,0.0005249236,0.003525823,0.0007474371],"domain_scores_gemma":[0.9777322,0.002071985,0.001436542,0.001136085,0.01380923,0.003813847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006996917,0.00007668309,0.006400377,0.0007078949,0.00007789967,0.0008677868,0.0004848592,0.0005002627,0.03289163,0.007555398,0.7332096,0.216528],"study_design_scores_gemma":[0.0001165961,0.00006984956,0.009783825,0.0002132728,0.00005505945,0.0006831239,0.0007230802,0.002439969,0.03655661,0.004791528,0.9445223,0.00004481654],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.1331971,0.00615239,0.09596256,0.1156164,0.05744826,0.002103451,0.03853143,0.0249423,0.5260462],"genre_scores_gemma":[0.2233438,0.003197725,0.07259966,0.006049218,0.007214809,0.0007257432,0.02663072,0.003649313,0.656589],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1432137,"threshold_uncertainty_score":0.4790976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05182299823782658,"score_gpt":0.3802464435849934,"score_spread":0.3284234453471668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}