{"id":"W4394978169","doi":"10.1101/2024.04.17.589937","title":"Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4′-CN-4-Aza-7,9-Dideazaadenosine <i>C</i> -Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Respiratory viral infections research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; Université Laval; Gilead Sciences","keywords":"Picornavirus; Prodrug; Rhinovirus; Potency; Virology; Nucleoside; Virus; In vivo; Respiratory system; In vitro; Medicine; Pharmacology; Biology; RNA; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311232,0.0003754917,0.0001921833,0.0001884782,0.00014083,0.0001830108,0.0002161394,0.0003003084,0.001163887],"category_scores_gemma":[0.00009835127,0.0001519833,0.0002033515,0.0001403454,0.0001615877,0.0001978662,0.0001215739,0.0003966183,0.0004956494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003445753,"about_ca_system_score_gemma":0.0004451404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000972511,"about_ca_topic_score_gemma":0.0009964325,"domain_scores_codex":[0.9999533,0.00000698379,0.00000433609,0.00001096657,0.00001061273,0.00001389258],"domain_scores_gemma":[0.9999683,0.000003558049,0.000005669069,0.000004065845,0.000006921706,0.00001144543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001507798,0.00007551918,0.00007786464,0.0001340447,0.000005696902,0.0001323915,0.00002832393,0.001702792,0.9849908,0.0009429969,0.00022466,0.01153406],"study_design_scores_gemma":[0.0001090898,0.001383546,0.0005192558,0.00001200479,0.00001655135,0.0002678626,0.000008999751,0.001182059,0.9863009,0.0001571972,0.01003329,0.000009192812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493649,0.005828504,0.02153491,0.000400758,0.0001618383,0.0005874438,0.001863686,0.0002073821,0.02005061],"genre_scores_gemma":[0.9714418,0.003105995,0.01405361,0.0001273137,0.00002808284,0.0001416086,0.001397434,0.00002395811,0.009680176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163887,"threshold_uncertainty_score":0.003893614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765517068020302,"score_gpt":0.2545886079562173,"score_spread":0.2369334372760143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}