{"id":"W4394987543","doi":"10.1101/2024.04.17.589809","title":"Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University","keywords":"Epitope; Immunology; Immunotherapy; Medicine; Autoimmunity; Antigen; Autoimmune hepatitis; Immune system; Hepatitis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00175209,0.0009789595,0.0008756944,0.0002078265,0.0003270768,0.0004855198,0.001382988,0.0007823825,0.00002601453],"category_scores_gemma":[0.0002503278,0.0008231499,0.000421635,0.0005827406,0.00008084216,0.00005269596,0.001887557,0.001379639,0.0000715997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522317,"about_ca_system_score_gemma":0.0008577548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003667889,"about_ca_topic_score_gemma":0.00001814161,"domain_scores_codex":[0.9958184,0.0002386423,0.001792106,0.0007328567,0.0003697395,0.001048252],"domain_scores_gemma":[0.9966838,0.00005905805,0.0008190231,0.002012557,0.0003258534,0.00009970948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001252606,0.0001870895,0.001650751,0.000839328,0.0008631052,0.00002020642,0.0005321556,0.006255936,0.9882303,0.0001385391,0.001098747,0.00005858914],"study_design_scores_gemma":[0.00374421,0.0004703831,0.02888813,0.002084147,0.0003809257,0.000001081378,0.0003554576,0.1250784,0.8069804,0.00002671422,0.02840303,0.003587162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9075896,0.05742806,0.03025494,0.000374766,0.001716895,0.002227229,0.0001462428,0.0002479414,0.00001431091],"genre_scores_gemma":[0.9331501,0.01443205,0.0508364,0.0004086892,0.0003562549,0.0005035794,0.00001020393,0.0002741854,0.00002854911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1812499,"threshold_uncertainty_score":0.999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149136818099783,"score_gpt":0.2266202347715385,"score_spread":0.2151288665905407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}